CM 40874 | CAS# 87286-08-6 | cephalosporin

MedKoo Cat#: 413206 | Name: CM-40874

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM 40874 is a new third generation cephalosporin with high activity on Enterobacteriaceae

Chemical Structure

CM-40874

CAS#87286-08-6

Theoretical Analysis

MedKoo Cat#: 413206

Name: CM-40874

CAS#: 87286-08-6

Chemical Formula: C25H26N6O8S3

Exact Mass: 634.0974

Molecular Weight: 634.69

Elemental Analysis: C, 47.31; H, 4.13; N, 13.24; O, 20.17; S, 15.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CM 40874; CM40874; CM-40874;

IUPAC/Chemical Name

(6R,7R)-3-(((1-allylpyridin-1-ium-2-yl)thio)methyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

InChi Key

RFLHEFOQQONDBP-SVZJCZCYSA-N

InChi Code

InChI=1S/C25H26N6O8S3/c1-4-8-30-9-6-5-7-15(30)40-10-13-12-42(38)21-17(20(33)31(21)18(13)22(34)35)28-19(32)16(14-11-41-24(26)27-14)29-39-25(2,3)23(36)37/h4-7,9,11,17,21H,1,8,10,12H2,2-3H3,(H4-,26,27,28,32,34,35,36,37)/b29-16-/t17-,21-,42?/m1/s1

SMILES Code

C=CC[N+]1=CC=CC=C1SCC(CS([C@@]2([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC(C(O)=O)(C)C)=O)[H])=O)=C(N2C3=O)C([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 634.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Duval J, Soussy CJ, Deforges L, Brun Y, Coulet M, Forey F, Thabaut A, Meyran M, Acar JF, Kitzis MD, et al. Etude multicentrique de l'activité antibactérienne d'une nouvelle céphalosporine: le CM 40874 [Multicenter study of the antibacterial activity of a new cephalosporin: CM 40874]. Pathol Biol (Paris). 1984 May;32(5):331-4. French. PMID: 6547524. 2: García-Rodriguez JA, García-Sánchez JE, García-García MI, García-Sánchez E, Munõz-Bellido JL, Trujillano I. Activity of CM-40874 against Enterobacter resistant to third generation cephalosporins. J Chemother. 1989 Jul;1(4 Suppl):357-9. PMID: 16312438. 3: Denis C, Lesage D, Delisle-Mizon F, Vergez P, Daguet GL. Application d'une méthode de transfert de membrane millipore à l'étude de l'activité de quatre bêta-lactamines sur Pseudomonas aeruginosa [Application of a millipore membrane transfer method to the study of the activity of 4 beta-lactams on Pseudomonas aeruginosa]. Pathol Biol (Paris). 1984 May;32(5):415-20. French. PMID: 6429614.