Prospidium chloride | CAS# 23476-83-7

MedKoo Cat#: 413178 | Name: Prospidium chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prospidium chloride is a dispiropiperazine derivative with potential cytostatic, anti-inflammatory and immune-suppressive properties. Although the exact mechanism of action of prospidin is not known, this agent was shown to interact with DNA, disrupting cell cycle at G2 phase, inhibiting phagocytic activity of monocytes and macrophage. Prospidin has good anti-lupus activity due to its immunosuppressive effects and was also used in refractory rheumatoid arthritis as an anti-rheumatic drug.

Chemical Structure

Prospidium chloride

CAS#23476-83-7 (chloride)

Theoretical Analysis

MedKoo Cat#: 413178

Name: Prospidium chloride

CAS#: 23476-83-7 (chloride)

Chemical Formula: C18H36Cl4N4O2

Exact Mass: 0.0000

Molecular Weight: 482.31

Elemental Analysis: C, 44.83; H, 7.52; Cl, 29.40; N, 11.62; O, 6.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

27115-14-6 (cation) 23476-83-7 (chloride)

Synonym

Prospidium chloride; NSC166100; NSC-166100; NSC 166100; Prospidine; 23476-83-7; Prospidin; PROSPIDIUM

IUPAC/Chemical Name

3,12-Bis(3-chloro-2-hydroxypropyl)-3,12-diaza-6,9-diazoniadispiro(5.2.5.2)hexadecane dichloride

InChi Key

QZJPEEOEZVHUAE-UHFFFAOYSA-L

InChi Code

InChI=1S/C18H36Cl2N4O2.2ClH/c19-13-17(25)15-21-1-5-23(6-2-21)9-11-24(12-10-23)7-3-22(4-8-24)16-18(26)14-20;;/h17-18,25-26H,1-16H2;2*1H/q+2;;/p-2

SMILES Code

OC(CCl)CN(CC1)CC[N+]1(CC2)CC[N+]32CCN(CC(O)CCl)CC3.[Cl-].[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 482.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Solomevich SO, Bychkovsky PM, Yurkshtovich TL, Golub NV, Mirchuk PY, Revtovich MY, Shmak AI. Biodegradable pH-sensitive prospidine-loaded dextran phosphate based hydrogels for local tumor therapy. Carbohydr Polym. 2019 Dec 15;226:115308. doi: 10.1016/j.carbpol.2019.115308. Epub 2019 Sep 9. PMID: 31582057. 2: Biegus J, Zymliński R, Sokolski M, Todd J, Cotter G, Metra M, Jankowska EA, Banasiak W, Ponikowski P. Serial assessment of spot urine sodium predicts effectiveness of decongestion and outcome in patients with acute heart failure. Eur J Heart Fail. 2019 May;21(5):624-633. doi: 10.1002/ejhf.1428. Epub 2019 Feb 17. PMID: 30773755. 3: Bychkovskiĭ PM, Iurkshtovich TL, Kladiev AA, Revtovich MIu. [Antineoplastic effect of hydrogel prospidin on Seidel ascites hepatoma used as a model]. Tsitologiia. 2012;54(3):230-5. Russian. PMID: 22645987. 4: Creech CB, Saye E, McKenna BD, Johnson BG, Jimenez N, Talbot TR, Bossung T, Gregory A, Edwards KM. One-year surveillance of methicillin-resistant Staphylococcus aureus nasal colonization and skin and soft tissue infections in collegiate athletes. Arch Pediatr Adolesc Med. 2010 Jul;164(7):615-20. doi: 10.1001/archpediatrics.2010.93. PMID: 20603460; PMCID: PMC3778501. 5: Malozhen SA. [Experience of single-stage use of cytostatics and implantation of Russian tube microdrainages in the surgery of refractory glaucoma]. Vestn Oftalmol. 2008 Nov-Dec;124(6):60-1. Russian. PMID: 19205408. 6: Leung SW, Chan CS, Lo SF, Pang CP, Pun TC, Yuen PM. Comparison of the different types of "laparoscopic total hysterectomy". J Minim Invasive Gynecol. 2007 Jan-Feb;14(1):91-6. doi: 10.1016/j.jmig.2006.09.003. PMID: 17218237. 7: Simonova OV, Nemtsov BF. [Psoriatic arthritis: combined treatment with prospidin and methotrexate]. Ter Arkh. 2005;77(8):60-4. Russian. PMID: 16206608. 8: Zaĭtsev VS, Tsinzerling VA, Tsvetkov EA. [Clinical and morphological characteristics of laryngeal papillomatosis in children]. Arkh Patol. 2005 Mar- Apr;67(2):27-9. Russian. PMID: 15938116. 9: Pavlenko NV. Fagotsitarnaia aktivnost' peritoneal'nykh makrofagov mysheĭ pri vvedenii bakterial'nykh vaktsin i prospidina [Phagocytic activity of mouse peritoneal macrophages under administration of bacterial vaccines and prospidin]. Mikrobiol Z. 2002 Sep-Oct;64(5):53-8. Russian. PMID: 12557494. 10: Zenger VG, Synebogov SV, Kadyrova EV. Sarkoma Kaposhi gortanoglotki [Kaposi's sarcoma of the laryngopharynx]. Vestn Otorinolaringol. 2002;(5):48-9. Russian. PMID: 12524971. 11: Kazakov DV, Belousova IE, Müller B, Palmedo G, Samtsov AV, Burg G, Kempf W. Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long-term follow-up and review of the literature. J Cutan Pathol. 2002 Apr;29(4):244-8. doi: 10.1034/j.1600-0560.2002.290408.x. PMID: 12028158. 12: Telegin GB, Kalinina AR, Ponomarenko NA, Ovsepyan AA, Smirnov SV, Tsybenko VV, Homeriki SG. New experimental model of multiple myeloma. Bull Exp Biol Med. 2001 Jun;131(6):609-12. doi: 10.1023/a:1012331425422. PMID: 11586419. 13: Bakaliuk OI, Shved MI, Hrebenyk MV. Inhibitory 3'--5'-tsAMF-fosfodiiesterazy v kompleksnomu likuvanni khvorykh na revmatoïdnyĭ artryt [3',5'-cAMP phosphodiesterase inhibitors in the combined treatment of patients with rheumatoid arthritis]. Lik Sprava. 1998 Aug;(6):34-7. Ukrainian. PMID: 9844866. 14: Nemtsov BF, Benenson EV, Timina OV. Sravnitel'naia éffektivnost' pul's-terapii prospidinom i metotreksatom pri revmatoidnom artrite (12-mesiachnoe kontroliruemoe issledovanie) [Pulse therapy with prospidin and methotrexate: comparative efficacy in rheumatoid arthritis (12-month controlled study)]. Klin Med (Mosk). 1998;76(8):24-8. Russian. PMID: 9770962. 15: Korovin SI. Primenenie ad"iuvantnoĭ terapii u bol'nykh s metastazami melanomy v regionarnykh limfaticheskikh uzlakh [Use of adjuvant therapy in patients with metastasis of melanoma to regional lymph nodes]. Klin Khir. 1998;(2):22-3. Russian. PMID: 9615073. 16: Antoniv VF, Lusinian NA, Vasyliv TIa, Panasiuk MO, Aksenov VM. Perekhodnaia papilloma gortani (osobennosti kliniki, diagnostika, lechenie) [Transitional laryngeal papilloma: clinical aspects, diagnosis and treatment]. Vestn Otorinolaringol. 1997;(5):40-2. Russian. PMID: 9432773. 17: Klochikhin AL, Markov GI. Mestnoe ispol'zovanie tsitostatikov na polimernoĭ osnove pri operatsiiakh u bolnykh rakom gortani [Local use of polymer-based cytostatic agents in surgical treatment of patients with laryngeal cancer]. Vestn Otorinolaringol. 1997;(3):42-5. Russian. PMID: 9229920. 18: Taresov DI, Lazarev VN. Gormonal'no-metabolicheskiĭ i immunnyĭ statusy pri retsidiviruiushchem papillomatoze gortani u deteĭ [Hormonal-metabolic and immune status in recurrent laryngeal papillomatosis in children]. Vestn Otorinolaringol. 1996 Jul-Aug;(4):22-4. Russian. PMID: 8966872. 19: Savenko IV, Tsvetkov EA. Ispol'zovanie sredstv immunokorrektsii v kompleksnom lechenii papillomatoza gortani u deteĭ [Use of immunomocorrection in the combined treatment of laryngeal papillomatosis in children]. Vestn Otorinolaringol. 1996 Jul-Aug;(4):12-4. Russian. PMID: 8966869. 20: Okun VM, Aak OV, Kozlov VYu. Determination of the anticancer drug prospidin in human tissue by high-performance capillary electrophoresis using derivatization. J Chromatogr B Biomed Appl. 1996 Jan 26;675(2):313-9. doi: 10.1016/0378-4347(95)00333-9. PMID: 8852720.