Synonym
Chlorisondamine chloride; SU3088; SU-3088; SU 3088
IUPAC/Chemical Name
1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride
InChi Key
DXXUGBPKQDTBQW-UHFFFAOYSA-L
InChi Code
InChI=1S/C14H20Cl4N2.2ClH/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[Cl-].[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
429.03
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Marenco T, Bernstein S, Cumming P, Clarke PB. Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats. Br J Pharmacol. 2000 Jan;129(1):147-55. doi: 10.1038/sj.bjp.0703005. PMID: 10694214; PMCID: PMC1621125.
2: Chadman KK, Woods JH, Stitzel J. Chlorisondamine inhibits the nicotine- induced stimulation of c-fos in the pigeon brain for up to 2 weeks. Nicotine Tob Res. 2007 Sep;9(9):927-36. doi: 10.1080/14622200701540838. PMID: 17763108.
3: Chadman KK, Woods JH. Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. J Pharmacol Exp Ther. 2004 Jan;308(1):73-8. doi: 10.1124/jpet.103.057307. Epub 2003 Oct 17. PMID: 14566012.
4: Clarke PB, Chaudieu I, el-Bizri H, Boksa P, Quik M, Esplin BA, Capek R. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111(2):397-405. doi: 10.1111/j.1476-5381.1994.tb14748.x. PMID: 7911713; PMCID: PMC1909961.
5: el-Bizri H, Clarke PB. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine administered in vivo. Br J Pharmacol. 1994 Feb;111(2):414-8. doi: 10.1111/j.1476-5381.1994.tb14750.x. PMID: 8004385; PMCID: PMC1909959.
6: el-Bizri H, Clarke PB. Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br J Pharmacol. 1994 Nov;113(3):917-25. doi: 10.1111/j.1476-5381.1994.tb17080.x. PMID: 7858886; PMCID: PMC1510460.
7: Gatineau E, Gong MC, Yiannikouris F. Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice. Hypertension. 2019 Oct;74(4):1014-1020. doi: 10.1161/HYPERTENSIONAHA.119.12906. Epub 2019 Aug 5. PMID: 31378099; PMCID: PMC6739191.
8: Woods AS, Moyer SC, Wang HY, Wise RA. Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. J Proteome Res. 2003 Mar- Apr;2(2):207-12. doi: 10.1021/pr025578h. PMID: 12716135.
9: CHIRONE E. L'IPERTENSIONE MALIGNA [MALIGNANT HYPERTENSION]. Policlinico Prat. 1964 Mar 2;71:325-38. Italian. PMID: 14143292.
10: Chaouloff F, Baudrie V, Coupry I. Effects of chlorisondamine and restraint on cortical [3H]ketanserin binding, 5-HT2A receptor-mediated head shakes, and behaviours in models of anxiety. Neuropharmacology. 1994 Mar-Apr;33(3-4):449-56. doi: 10.1016/0028-3908(94)90075-2. PMID: 7984283.
