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MedKoo Cat#: 464112 | Name: Chlorhexidine-d8 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively). Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml). It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay. Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.

Chemical Structure

Chlorhexidine-d8 HCl
Chlorhexidine-d8 HCl
CAS#2012598-75-1

Theoretical Analysis

MedKoo Cat#: 464112

Name: Chlorhexidine-d8 HCl

CAS#: 2012598-75-1

Chemical Formula: C22H24D8Cl4N10

Exact Mass: 584.2068

Molecular Weight: 586.42

Elemental Analysis: C, 45.06; H, 6.87; Cl, 24.18; N, 23.89

Price and Availability

Size Price Availability Quantity
1mg USD 650.00 2 Weeks
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Synonym
Chlorhexidine-d8 hydrochloride; Chlorhexidine d8 hydrochloride; Chlorhexidine-d8 HCl; Chlorhexidine d8 HCl; CHX-d8; CHX d8;
IUPAC/Chemical Name
N1,N14-bis(4-chlorophenyl-d4)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, dihydrochloride
InChi Key
WJLVQTJZDCGNJN-ZYNYSASXSA-N
InChi Code
InChI=1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H/i5D,6D,7D,8D,9D,10D,11D,12D;;
SMILES Code
ClC(C([2H])=C1[2H])=C(C([2H])=C1NC(NC(NCCCCCCNC(NC(NC2=C(C([2H])=C(Cl)C([2H])=C2[2H])[2H])=N)=N)=N)=N)[2H].Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 586.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Imran E, Khurshid Z, Adanir N, Ashi H, Almarzouki N, Baeshen HA. Dental Practitioners' Knowledge, Attitude and Practices for Mouthwash Use Amidst the COVID-19 Pandemic. Risk Manag Healthc Policy. 2021 Feb 15;14:605-618. doi: 10.2147/RMHP.S287547. PMID: 33623451; PMCID: PMC7895912. 2: Mehta DL, Abraham S, Kamble AB, Vaswani SD, Najan HB, Mehta PL. Spectrophotometric analysis of the color stability of white mineral trioxide aggregate in contact with four different irrigating solutions - An in vitro study. J Conserv Dent. 2020 Jul-Aug;23(4):377-383. doi: 10.4103/JCD.JCD_412_20. Epub 2021 Jan 16. PMID: 33623240; PMCID: PMC7883782. 3: Serane V T, Rajasekaran R, Vijayadevagaran V, Kothendaraman B. Peripheral intravenous cannulae in neonates: To splint or not? J Vasc Access. 2021 Feb 23:1129729821996926. doi: 10.1177/1129729821996926. Epub ahead of print. PMID: 33619983. 4: Terlep S, Hympanova M, Dogsa I, Pajk F, Stopar D. Photoacoustic removal of Enterococcus faecalis biofilms from titanium surface with an Er:YAG laser using super short pulses. Lasers Med Sci. 2021 Feb 22. doi: 10.1007/s10103-021-03265-6. Epub ahead of print. PMID: 33619682. 5: Kimyai S, Mohammadi N, Bahari M, Pesyanian E, Pesyanian F. Effect of Cavity Disinfection with Chlorhexidine on Marginal Gap of Class V Composite Restorations Bonded with a Universal Adhesive Using Self-Etch and Etch-and-Rinse Bonding Strategy. Front Dent. 2020 Feb;17(3):1-7. doi: 10.18502/fid.v17i1.3963. Epub 2020 Feb 14. PMID: 33615301; PMCID: PMC7882204. 6: Milani S, Seraj B, Khoshlafz Z, Abazarian N. Effect of Dentin Pretreatment with Chlorhexidine on Push-Out Bond Strength of Composite Restorations in Severely Damaged Primary Anterior Teeth. Front Dent. 2020 Sep;17(23):1-7. doi: 10.18502/fid.v17i23.4413. Epub 2020 Sep 25. PMID: 33615300; PMCID: PMC7883659. 7: Pietsch F, Heidrich G, Nordholt N, Schreiber F. Prevalent Synergy and Antagonism Among Antibiotics and Biocides in Pseudomonas aeruginosa. Front Microbiol. 2021 Feb 4;11:615618. doi: 10.3389/fmicb.2020.615618. PMID: 33613467; PMCID: PMC7889964. 8: Pérez-Köhler B, Benito-Martínez S, García-Moreno F, Rodríguez M, Pascual G, Bellón JM. Antibacterial polypropylene mesh fixation with a cyanoacrylate adhesive improves its response to infection. Surgery. 2021 Feb 18:S0039-6060(21)00030-1. doi: 10.1016/j.surg.2021.01.012. Epub ahead of print. PMID: 33612292. 9: Tallarico M, Lumbau AI, Park CJ, Puddu A, Sanseverino F, Amarena R, Meloni SM. In vitro evaluation of bioburden, three-dimensional stability, and accuracy of surgical templates without metallic sleeves after routinely infection control activities. Clin Implant Dent Relat Res. 2021 Feb 21. doi: 10.1111/cid.12986. Epub ahead of print. PMID: 33611832. 10: Demenech LS, de Feitas JV, Tomazinho FSF, Baratto-Filho F, Gabardo MCL. Postoperative pain after endodontic treatment under irrigation with 8.25% sodium hypochlorite and other solutions: A randomized clinical trial. J Endod. 2021 Feb 16:S0099-2399(21)00082-0. doi: 10.1016/j.joen.2021.02.004. Epub ahead of print. PMID: 33607121. 11: Rostamifar S, Azad A, Bazrafkan A, Modaresi F, Atashpour S, Jahromi ZK. New Strategy of Reducing Biofilm Forming Bacteria in Oral Cavity by Bismuth Nanoparticles. Biomed Res Int. 2021 Feb 2;2021:6695692. doi: 10.1155/2021/6695692. PMID: 33604383; PMCID: PMC7872758. 12: Kleinhout MY, Stevens MM, Osman KA, Adu-Bonsaffoh K, Groenendaal F, Biza Zepro N, Rijken MJ, Browne JL. Evidence-based interventions to reduce mortality among preterm and low-birthweight neonates in low-income and middle-income countries: a systematic review and meta-analysis. BMJ Glob Health. 2021 Feb;6(2):e003618. doi: 10.1136/bmjgh-2020-003618. PMID: 33602687. 13: Kim S, Choi C, Cha Y, Chang JS. The efficacy of convenient cleaning methods applicable for customized abutments: an in vitro study. BMC Oral Health. 2021 Feb 18;21(1):78. doi: 10.1186/s12903-021-01436-z. PMID: 33602211; PMCID: PMC7890105. 14: Esposito F, Boccuzzi M, Riad A, Preda C, Chiesa A, Oldoini G, Genovesi AM. Airborne contamination during a full-mouth disinfection session: Pilot study before COVID-19 pandemic. J Biol Regul Homeost Agents. 2021 Feb 19;35(1). doi: 10.23812/20-625-L. Epub ahead of print. PMID: 33601877. 15: Caiazzo A, Canullo L; Consensus Meeting Group, Pesce P. Consensus Report by the Italian Academy of Osseointegration on the Use of Antibiotics and Antiseptic Agents in Implant Surgery. Int J Oral Maxillofac Implants. 2021 Jan- Feb;36(1):103-105. doi: 10.11607/jomi.8264. PMID: 33600529. 16: Tumuhamye J, Steinsland H, Bwanga F, Tumwine JK, Ndeezi G, Mukunya D, Namugga O, Kasede AN, Sommerfelt H, Nankabirwa V. Vaginal colonization with antimicrobial-resistant bacteria among women in labor in central Uganda: prevalence and associated factors. Antimicrob Resist Infect Control. 2021 Feb 17;10(1):37. doi: 10.1186/s13756-021-00897-9. PMID: 33597029; PMCID: PMC7887551. 17: Mirhashemi AH, Saffar Shahroudi A, Shahpoorzadeh K, Habibi Khameneh N. Comparative evaluation of force decay pattern in orthodontic active tiebacks exposed to five different mouth rinses: An in vitro Study. J Dent Res Dent Clin Dent Prospects. 2020 Fall;14(4):244-249. doi: 10.34172/joddd.2020.048. Epub 2020 Dec 9. PMID: 33575015; PMCID: PMC7867684. 18: Cavalcante-Leão BL, de Araujo CM, Basso IB, Schroder AG, Guariza-Filho O, Ravazzi GC, Gonçalves FM, Zeigelboim BS, Santos RS, Stechman-Neto J. Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic review. J Clin Exp Dent. 2021 Feb 1;13(2):e179-e189. doi: 10.4317/jced.57406. PMID: 33575003; PMCID: PMC7864359. 19: Rehman O, Ichhpujani P, Nayyar S, Kumar S. COVID-19 pandemic and lockdown: Changing trends in Ophthalmology for in-patient and emergency services. Indian J Ophthalmol. 2021 Mar;69(3):701-705. doi: 10.4103/ijo.IJO_3009_20. PMID: 33595504. 20: Isaza D, DiGangi BA, Isaza N, Isaza R. Impact of surgical preparatory rinses with isopropyl alcohol or water on perioperative body temperature in pediatric female dogs and cats. Vet Anaesth Analg. 2020 Dec 29:S1467-2987(20)30283-X. doi: 10.1016/j.vaa.2020.11.006. Epub ahead of print. PMID: 33589395.