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MedKoo Cat#: 413165 | Name: Clorotepine (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clorotepine (free base) is a major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses.

Chemical Structure

Clorotepine (free base)
Clorotepine (free base)
CAS#13448-22-1 (free base)

Theoretical Analysis

MedKoo Cat#: 413165

Name: Clorotepine (free base)

CAS#: 13448-22-1 (free base)

Chemical Formula: C19H21ClN2S

Exact Mass: 344.1114

Molecular Weight: 344.90

Elemental Analysis: C, 66.17; H, 6.14; Cl, 10.28; N, 8.12; S, 9.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
13448-22-1 (free base) 42505-79-3 (mesylate)
Synonym
Clorotepine (free base); Clotepin; Octoclothepin
IUPAC/Chemical Name
1-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
InChi Key
XRYLGRGAWQSVQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21ClN2S/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19/h2-7,13,17H,8-12H2,1H3
SMILES Code
CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ Jr, Shen Y, Meltzer HY, Sibley DR. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. PMID: 7908055. 2: Viswanathan G, Yadav S, Raghunand TR. Identification of Mycobacterial Genes Involved in Antibiotic Sensitivity: Implications for the Treatment of Tuberculosis with β-Lactam-Containing Regimens. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00425-17. doi: 10.1128/AAC.00425-17. PMID: 28438925; PMCID: PMC5487644. 3: Risgaard R, Ettrup A, Balle T, Dyssegaard A, Hansen HD, Lehel S, Madsen J, Pedersen H, Püschl A, Badolo L, Bang-Andersen B, Knudsen GM, Kristensen JL. Radiolabelling and PET brain imaging of the α₁-adrenoceptor antagonist Lu AE43936. Nucl Med Biol. 2013 Jan;40(1):135-40. doi: 10.1016/j.nucmedbio.2012.09.010. Epub 2012 Nov 17. PMID: 23165140. 4: Nisa S, Blokpoel MC, Robertson BD, Tyndall JD, Lun S, Bishai WR, O'Toole R. Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. J Antimicrob Chemother. 2010 Nov;65(11):2347-58. doi: 10.1093/jac/dkq311. Epub 2010 Sep 1. PMID: 20810423; PMCID: PMC2980951. 5: Kristensen JL, Püschl A, Jensen M, Risgaard R, Christoffersen CT, Bang- Andersen B, Balle T. Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors. J Med Chem. 2010 Oct 14;53(19):7021-34. doi: 10.1021/jm100652h. PMID: 20857909. 6: Tehan BG, Lloyd EJ, Wong MG. Molecular field analysis of clozapine analogs in the development of a pharmacophore model of antipsychotic drug action. J Mol Graph Model. 2001;19(5):417-26, 468. doi: 10.1016/s1093-3263(00)00101-7. PMID: 11552690. 7: Zapletálek M, Zbytovský J, Kindernayová H. Clinical and experimental study of oxyprothepine. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1980;23(4):487-90. PMID: 6111116. 8: Metysová J, Metys J, Dlabac A, Kazdová E, Valchár M. Pharmacological properties of a potent neuroleptic drug octoclothepin. Acta Biol Med Ger. 1980;39(6):723-40. PMID: 6893891. 9: Polák L, Molcan J. Clonidine in hyperkinetic children. Act Nerv Super (Praha). 1990 Mar;32(1):66-7. PMID: 1973018. 10: Bøgesø KP, Liljefors T, Arnt J, Hyttel J, Pedersen H. Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists. J Med Chem. 1991 Jul;34(7):2023-30. doi: 10.1021/jm00111a015. PMID: 1676758.