Chlorphenamine | CAS# 132-22-9 | histamine H1 antagonist

MedKoo Cat#: 413159 | Name: Chlorphenamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorphenamine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

Chemical Structure

Chlorphenamine

CAS#132-22-9 (free)

Theoretical Analysis

MedKoo Cat#: 413159

Name: Chlorphenamine

CAS#: 132-22-9 (free)

Chemical Formula: C16H19ClN2

Exact Mass: 274.1237

Molecular Weight: 274.79

Elemental Analysis: C, 69.94; H, 6.97; Cl, 12.90; N, 10.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

113-92-8 (maleate) 132-22-9 (free)

Synonym

Chlorphenamine; HSDB3032; HSDB-3032; HSDB 3032

IUPAC/Chemical Name

2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-

InChi Key

SOYKEARSMXGVTM-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3

SMILES Code

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 274.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Picon PD, Costa MB, da Veiga Picon R, Fendt LC, Suksteris ML, Saccilotto IC, Dornelles AD, Schmidt LF. Symptomatic treatment of the common cold with a fixed- dose combination of paracetamol, chlorphenamine and phenylephrine: a randomized, placebo-controlled trial. BMC Infect Dis. 2013 Nov 22;13:556. doi: 10.1186/1471-2334-13-556. PMID: 24261438; PMCID: PMC4222817. 2: Monte AA, Chuang R, Bodmer M. Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review. Br J Clin Pharmacol. 2010 Dec;70(6):794-8. doi: 10.1111/j.1365-2125.2010.03747.x. PMID: 21175434; PMCID: PMC3014062. 3: Chlorphenamine. Nurs Times. 2005 Aug 9-15;101(32):31. PMID: 16119587. 4: Van Toor BS, Buchwald A, Stengele E, Trenk D, Gercek C, de Mey CM. Systemic bioavailability of nasally applied chlorphenamine maleate (0.4% nasal spray) relative to tablets administered perorally. Int J Clin Pharmacol Ther. 2001 Apr;39(4):173-8. doi: 10.5414/cpp39173. PMID: 11332874. 5: Ding Y, Huang K, Chen L, Yang J, Xu WY, Xu XJ, Duan R, Zhang J, He Q. Simultaneous quantitative analysis of dextromethorphan, dextrorphan and chlorphenamine in human plasma by liquid chromatography-electrospray tandem mass spectrometry. Biomed Chromatogr. 2014 Mar;28(3):446-52. doi: 10.1002/bmc.3054. Epub 2013 Nov 20. PMID: 24254834. 6: Fanali S, Chankvetadze B. Some thoughts about enantioseparations in capillary electrophoresis. Electrophoresis. 2019 Sep;40(18-19):2420-2437. doi: 10.1002/elps.201900144. Epub 2019 May 21. PMID: 31081552. 7: Yin C, Tang C, Wu X. HPLC determination of aminophylline, methoxyphenamine hydrochloride, noscapine and chlorphenamine maleate in compound dosage forms with an aqueous-organic mobile phase. J Pharm Biomed Anal. 2003 Sep 15;33(1):39-43. doi: 10.1016/s0731-7085(03)00352-2. PMID: 12946529. 8: Huang YQ, You JQ, Zhang J, Sun W, Ding L, Feng YQ. Coupling frontal elution paper chromatography with desorption corona beam ionization mass spectrometry for rapid analysis of chlorphenamine in herbal medicines and dietary supplements. J Chromatogr A. 2011 Oct 14;1218(41):7371-6. doi: 10.1016/j.chroma.2011.08.067. Epub 2011 Aug 25. PMID: 21899852. 9: Brown VL, Orton DI. Cutaneous adverse drug reaction to oral chlorphenamine detected with patch testing. Contact Dermatitis. 2005 Jan;52(1):49-50. doi: 10.1111/j.0105-1873.2005.0483f.x. PMID: 15701135. 10: De Beer JO, Vandenbroucke CV, Massart DL. Experimental design for the rapid selection of separation conditions for methyl and propyl parahydroxybenzoate, phenylephrine hydrochloride and chlorphenamine maleate by ion-pair liquid chromatography. J Pharm Biomed Anal. 1994 Nov;12(11):1379-96. doi: 10.1016/0731-7085(94)00089-1. PMID: 7849134.