MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 463952 | Name: Thiazinamium metilsulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiazinamium metilsulfate is a drug with antihistaminic and anticholinergic properties.

Chemical Structure

Thiazinamium metilsulfate
Thiazinamium metilsulfate
CAS#58-34-4

Theoretical Analysis

MedKoo Cat#: 463952

Name: Thiazinamium metilsulfate

CAS#: 58-34-4

Chemical Formula: C19H26N2O4S2

Exact Mass: 410.1334

Molecular Weight: 410.55

Elemental Analysis: C, 55.59; H, 6.38; N, 6.82; O, 15.59; S, 15.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Thiazinamium metilsulfate; Multergan; Multezin; Padisal; Prothazin methosulfate; Valan;
IUPAC/Chemical Name
N,N,N-trimethyl-1-(10H-phenothiazin-10-yl)propan-2-aminium methyl sulfate
InChi Key
BVIDQAVCCRUFGU-UHFFFAOYSA-M
InChi Code
InChI=1S/C18H23N2S.CH4O4S/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19;1-5-6(2,3)4/h5-12,14H,13H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1
SMILES Code
COS(=O)([O-])=O.CC([N+](C)(C)C)CN1c2c(Sc3c1cccc3)cccc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lara FJ, García-Campaña AM, Alés-Barrero F, Bosque-Sendra JM. Development and validation of a capillary electrophoresis method for the determination of phenothiazines in human urine in the low nanogram per milliliter concentration range using field-amplified sample injection. Electrophoresis. 2005 Jun;26(12):2418-29. doi: 10.1002/elps.200500098. PMID: 15924366. 2: Smet E, Baeyens WR, Van der Weken G, Kiekens F, Vervaet C, Remon JP. A validated HPLC method for the determination of thiazinamium methylsulphate in pharmaceutical preparations. J Pharm Biomed Anal. 2000 Aug 1;23(1):175-83. doi: 10.1016/s0731-7085(00)00267-3. PMID: 10898168. 3: Gimeno F, van Veenen R, Steenhuis EJ, Berg WC. Comparison of disodium cromoglycate, terbutaline and thiazinamium in the prevention of exercise-induced asthma and its relation to non-specific bronchial responsiveness. Respiration. 1985;48(2):108-15. doi: 10.1159/000194809. PMID: 2865780. 4: Jonkman JH, Westenberg HG, Rijntjes NV, van der Kleijn E, Lindeboom SF. Whole body distribution of the quaternary ammonium compound thiazinamium (N-methylpromethazine) and promethazine in monkey and mice. Arzneimittelforschung. 1983;33(2):223-8. PMID: 6133524. 5: Jonkman JH, Wijsbeek J, De Zeeuw RA, Van Bork LE, Orie NG. Metabolism and excretion of the quaternary ammonium compound thiazinamium methylsulfate (Multergan) in man. II. Oral and rectal administration. Pharm Weekbl Sci. 1982 Oct 22;4(5):129-34. doi: 10.1007/BF01959030. PMID: 6128714. 6: Jonkman JH, Wijsbeek J, De Zeeuw RA, Van Bork LE, Orie NG, Soeterboek AM, Bender J. Metabolism and excretion of the quaternary ammonium compound thiazinamium methylsulfate (Multergan) in man. I. Parenteral administration. Pharm Weekbl Sci. 1982 Oct 22;4(5):122-8. doi: 10.1007/BF01959029. PMID: 6128713. 7: Jonkman JH, Westenberg HG, Van Der Kleyn E. Hepatic first-pass effect of thiazinamium methylsulfate (N-methylpromethazine methylsulfate) in dogs. J Pharm Sci. 1981 Aug;70(8):947-9. doi: 10.1002/jps.2600700831. PMID: 6118426. 8: Jonkman JH, van Bork LE, Wijsbeek J, Bolhuis-de Vries AS, de Zeeuw RA, Orie NG, Cox HL. First-pass effect after rectal administration of thiazinamium methylsulfate. J Pharm Sci. 1979 Jan;68(1):69-72. doi: 10.1002/jps.2600680121. PMID: 758468. 9: Jonkman JH, Van Bork LE, Wijsbeek J, De Zeeuw RK, Orie NG. Variations in the bioavailability of thiazinamium methylsulfate. Clin Pharmacol Ther. 1977 Apr;21(4):457-63. doi: 10.1002/cpt1977214457. PMID: 849677. 10: Jonkman JH, van Bork LE, Wijsbeek J, de Zeeuw RA, Orie NG, Cox HL. "First pass effect" after rectal administration of thiazinamium methylsulphate [proceedings]. J Pharm Pharmacol. 1976 Dec;28 Suppl:56P. PMID: 12333. 11: Jonkman JG, Wijsbeek J, Hollenbeek S, de Boer SH, de Zeeuw RA, Van Bork LE, Orie NG. Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine. J Pharm Pharmacol. 1975 Nov;27(11):849-54. doi: 10.1111/j.2042-7158.1975.tb10228.x. PMID: 1494. 12: Désiré B, Blanchet G. Interaction de l'acétylcholinestérase avec le chlorhydrate de thioridazine et le méthylsulfate de thiazinamium [The interaction of acetylcholinesterase with thioridazine chlorohydrate and thiazinamium methylsulfate]. C R Acad Hebd Seances Acad Sci D. 1975 Oct 13;281(15):1135-8. French. PMID: 813887. 13: Jonkman JH, Wijsbeek U, Brouwer SH, De Zeeuw RA. Proceedings: Bioavailability of the quaternary ammonium compound thiazinamium methylsulphate (Multergan) after oral and intramuscular administration. J Pharm Pharmacol. 1974 Dec;26 Suppl:63P. doi: 10.1111/j.2042-7158.1974.tb10085.x. PMID: 4156742. 14: Dessouky YM, Mousa BA, Nour el-Din HM. Dye salt formation as a general method for colorimetric determination of antihistaminics. Part 2: Spectrophotometric determination of thenalidine maleate and thiazinamium methylsulphate in pure and dosage forms. Pharmazie. 1974 Sep;29(9):579-80. PMID: 4154007.