Synonym
Cefuzonam sodium; Cosmosin; CL 251931 sodium salt; CZON; L-105; L 105; L105; LJC-10305;
IUPAC/Chemical Name
sodium (6R,7R)-3-(((1,2,3-thiadiazol-5-yl)thio)methyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
BCMSQWPLFBUUKW-IXLPVNPSSA-M
InChi Code
InChI=1S/C16H15N7O5S4.Na/c1-28-21-9(7-5-31-16(17)19-7)12(24)20-10-13(25)23-11(15(26)27)6(4-30-14(10)23)3-29-8-2-18-22-32-8;/h2,5,10,14H,3-4H2,1H3,(H2,17,19)(H,20,24)(H,26,27);/q;+1/p-1/b21-9-;/t10-,14-;/m1./s1
SMILES Code
O=C(C(N12)=C(CSC3=CN=NS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)[O-].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
535.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Inagaki K, Kambara M, Mizuno M, Okuda J, Gill MA, Nishida M. Compatibility and stability of ranitidine hydrochloride with six cephalosporins during simulated y-site administration. Int J Pharm Compd. 1998 Jul-Aug;2(4):318-21. PubMed PMID: 23989642.
2: Kitano K, Shirao Y, Kawasaki K. Non-toxic concentrations of cephem antibiotics for intravitreal application--evaluation by in vitro electroretinogram. Ophthalmic Res. 1995;27 Suppl 1:128-35. PubMed PMID: 8577450.
3: Miyake Y, Okada M, Iseda S, Suginaka H. Effects of cefuzonam on peptidoglycan cross-linking reactions in gram-negative bacilli. Chemotherapy. 1992;38(1):17-20. PubMed PMID: 1617999.
4: Morita M, Aritomi H. Bone cement not weakened by cefuzonam powder. Acta Orthop Scand. 1991 Jun;62(3):232-7. PubMed PMID: 2042464.
5: Sugihara I, Ueda K, Saiki H, Hanada M, Doi H, Ishibashi T, Nakayama M, Numa R, Yamauchi K, Kawata R, et al. [Comparison of intraocular penetration level of cefuzonam sodium and cefotiam after intravenous and subconjunctival injection]. Nippon Ganka Gakkai Zasshi. 1990 Feb;94(2):211-8. Japanese. PubMed PMID: 2368649.