MedKoo Cat#: 596479 | Name: Cefuzonam sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefuzonam sodium is a second-generation cephalosporin antibiotic, has broad spectrum on Gram-positive or -negative bacteria and may also be effective against Staphylococcus aureus against which third generation cephalosporins are largely ineffective.

Chemical Structure

Cefuzonam sodium
CAS#82219-81-6 (Na+)

Theoretical Analysis

MedKoo Cat#: 596479

Name: Cefuzonam sodium

CAS#: 82219-81-6 (Na+)

Chemical Formula: C16H14N7NaO5S4

Exact Mass:

Molecular Weight: 535.56

Elemental Analysis: C, 35.88; H, 2.63; N, 18.31; Na, 4.29; O, 14.94; S, 23.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Cefuzonam sodium; Cosmosin; CL 251931 sodium salt; CZON; L-105; L 105; L105; LJC-10305;
IUPAC/Chemical Name
sodium (6R,7R)-3-(((1,2,3-thiadiazol-5-yl)thio)methyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
BCMSQWPLFBUUKW-IXLPVNPSSA-M
InChi Code
InChI=1S/C16H15N7O5S4.Na/c1-28-21-9(7-5-31-16(17)19-7)12(24)20-10-13(25)23-11(15(26)27)6(4-30-14(10)23)3-29-8-2-18-22-32-8;/h2,5,10,14H,3-4H2,1H3,(H2,17,19)(H,20,24)(H,26,27);/q;+1/p-1/b21-9-;/t10-,14-;/m1./s1
SMILES Code
O=C(C(N12)=C(CSC3=CN=NS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 535.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Inagaki K, Kambara M, Mizuno M, Okuda J, Gill MA, Nishida M. Compatibility and stability of ranitidine hydrochloride with six cephalosporins during simulated y-site administration. Int J Pharm Compd. 1998 Jul-Aug;2(4):318-21. PubMed PMID: 23989642. 2: Kitano K, Shirao Y, Kawasaki K. Non-toxic concentrations of cephem antibiotics for intravitreal application--evaluation by in vitro electroretinogram. Ophthalmic Res. 1995;27 Suppl 1:128-35. PubMed PMID: 8577450. 3: Miyake Y, Okada M, Iseda S, Suginaka H. Effects of cefuzonam on peptidoglycan cross-linking reactions in gram-negative bacilli. Chemotherapy. 1992;38(1):17-20. PubMed PMID: 1617999. 4: Morita M, Aritomi H. Bone cement not weakened by cefuzonam powder. Acta Orthop Scand. 1991 Jun;62(3):232-7. PubMed PMID: 2042464. 5: Sugihara I, Ueda K, Saiki H, Hanada M, Doi H, Ishibashi T, Nakayama M, Numa R, Yamauchi K, Kawata R, et al. [Comparison of intraocular penetration level of cefuzonam sodium and cefotiam after intravenous and subconjunctival injection]. Nippon Ganka Gakkai Zasshi. 1990 Feb;94(2):211-8. Japanese. PubMed PMID: 2368649.