MedKoo Cat#: 463949 | Name: Dibenamine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse.

Chemical Structure

Dibenamine HCl
CAS#55-43-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 463949

Name: Dibenamine HCl

CAS#: 55-43-6 (HCl)

Chemical Formula: C16H19Cl2N

Exact Mass: 295.0895

Molecular Weight: 296.24

Elemental Analysis: C, 64.87; H, 6.47; Cl, 23.93; N, 4.73

Price and Availability

Size Price Availability Quantity
5g USD 350.00 2 Weeks
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Synonym
Dibenamine HCl; NSC 11491; NSC-11491; NSC11491; Sympatholytin; Dibenzylchlorethamine hydrochloride; Dibenzylchlorethylamine hydrochloride
IUPAC/Chemical Name
N,N-dibenzyl-2-chloroethan-1-amine hydrochloride
InChi Key
LZXCEBPGNFLHEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18ClN.ClH/c17-11-12-18(13-15-7-3-1-4-8-15)14-16-9-5-2-6-10-16;/h1-10H,11-14H2;1H
SMILES Code
ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. SEARS ML, BARANY EH. Outflow resistance and adrenergic mechanisms. Effects of sympathectomy, N-(2-chloroethyl) dibenzylamine hydrochloride (dibenamine) and dichloroiso-proterenol on the outflow resistance of the rabbit eye. Arch Ophthalmol. 1960 Dec;64:839-48. doi: 10.1001/archopht.1960.01840010841004. PMID: 13749511. 2. HANNO HA. Auricular fibrillation following administration of dibenamine hydrochloride. J Am Med Assoc. 1949 Dec 17;141(16):1144. doi: 10.1001/jama.1949.62910160001008. PMID: 15394681. 3. DE VLEESCHHOUWER GR. Pharmacology of dibenzyl-beta-chloroethylamine hydrochloride (dibenamine). Proc Soc Exp Biol Med. 1947 Oct;66(1):151. doi: 10.3181/00379727-66-16014p. PMID: 20270705. 4. RAAB W, HUMPHREYS RJ. Drug action upon myocardial epinephreine-sympathin concentration and heart rate (nitro-glycerine, papverine, priscol, dibenamine hydrochloride). J Pharmacol Exp Ther. 1947 Jan;89(1):64-76. PMID: 20281340.