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MedKoo Cat#: 413144 | Name: Cloperastine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cloperastine is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, and in some European countries.

Chemical Structure

Cloperastine
Cloperastine
CAS#3703-76-2 (free base)

Theoretical Analysis

MedKoo Cat#: 413144

Name: Cloperastine

CAS#: 3703-76-2 (free base)

Chemical Formula: C20H24ClNO

Exact Mass: 329.1546

Molecular Weight: 329.87

Elemental Analysis: C, 72.82; H, 7.33; Cl, 10.75; N, 4.25; O, 4.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
14984-68-0 (HCl) 3703-76-2 (free base)
Synonym
Cloperastine; cloperastin; cloperastine hydrochloride; cloperastine fendizoate; HT11; HT-11; HT 11
IUPAC/Chemical Name
1- 2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl piperidine
InChi Key
FLNXBVJLPJNOSI-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24ClNO/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22/h1,3-4,7-12,20H,2,5-6,13-16H2
SMILES Code
ClC1=CC=C(C=C1)C(OCCN2CCCCC2)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 329.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Induced hemichorea by cloperastine overuse. 2. Identification and quantification of five impurities in cloperastine hydrochloride. 3. Enantioselective LC-MS/MS method for the determination of cloperastine enantiomers in rat plasma and its pharmacokinetic application. 4. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. 5. Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol. 6. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. 7. Pharmacological and clinical overview of cloperastine in treatment of cough. Catania MA, Cuzzocrea S. 8. Cloperastine-based cough syrup and acute dystonic reactions. 9. Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats. 10. On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.