MedKoo Cat#: 463944 (HCl) | Name: Br-Verapamil HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Br-Verapamil HCl is a novel CaV channel blocker, binding in the central cavity of the pore on the intracellular side of the selectivity filter, physically blocking the ion-conducting pathway.

Chemical Structure

Br-Verapamil HCl
Br-Verapamil HCl
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463944 (HCl)

Name: Br-Verapamil HCl

CAS#: unknown

Chemical Formula: C25H34BrClN2O2

Exact Mass: 508.1492

Molecular Weight: 509.91

Elemental Analysis: C, 58.89; H, 6.72; Br, 15.67; Cl, 6.95; N, 5.49; O, 6.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Br-Verapamil HCl; Br Verapamil HCl;
IUPAC/Chemical Name
2-(2-bromophenyl)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropylpentanenitrile hydrochloride
InChi Key
HERCCRZFFCUTNE-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H33BrN2O2.ClH/c1-19(2)25(18-27,21-9-6-7-10-22(21)26)14-8-15-28(3)16-13-20-11-12-23(29-4)24(17-20)30-5;/h6-7,9-12,17,19H,8,13-16H2,1-5H3;1H
SMILES Code
N#CC(C(C)C)(C1=CC=CC=C1Br)CCCN(CCC2=CC=C(OC)C(OC)=C2)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 509.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tikhonov DB, Lin L, Yang DSC, Yuchi Z, Zhorov BS. Phenylalkylamines in calcium channels: computational analysis of experimental structures. J Comput Aided Mol Des. 2020 Nov;34(11):1157-1169. doi: 10.1007/s10822-020-00330-0. Epub 2020 Jul 10. PMID: 32648151. 2. Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA. Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature. 2016 Sep 1;537(7618):117-121. doi: 10.1038/nature19102. Epub 2016 Aug 24. PMID: 27556947; PMCID: PMC5161592.