MedKoo Cat#: 534832 | Name: Pregnadienol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pregnadienol is a bioactive chemical.

Chemical Structure

Pregnadienol
CAS#21321-88-0

Theoretical Analysis

MedKoo Cat#: 534832

Name: Pregnadienol

CAS#: 21321-88-0

Chemical Formula: C21H32O

Exact Mass: 300.2453

Molecular Weight: 300.49

Elemental Analysis: C, 83.94; H, 10.73; O, 5.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pregnadienol
IUPAC/Chemical Name
Pregna-5,20-dien-3-ol, (3beta)-
InChi Key
AXSZNOPJKXHJAB-UZCUGSDUSA-N
InChi Code
InChI=1S/C21H32O/c1-4-14-6-8-18-17-7-5-15-13-16(22)9-11-21(15,3)19(17)10-12-20(14,18)2/h4-5,14,16-19,22H,1,6-13H2,2-3H3/t14-,16-,17-,18-,19-,20+,21-/m0/s1
SMILES Code
C=C[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bratoeff E, Cabeza M, Pérez-Ornelas V, Recillas S, Heuze I. In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5alpha- reductase inhibitors. J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):275-81. doi: 10.1016/j.jsbmb.2008.06.014. Epub 2008 Jul 3. PMID: 18644453. 2: Garrido M, González-Arenas A, Camacho-Arroyo I, Cabeza M, Alcaraz B, Bratoeff E. Effect of new hybrids based on 5,16-pregnadiene scaffold linked to an anti- inflammatory drug on the growth of a human astrocytoma cell line (U373). Eur J Med Chem. 2015 Mar 26;93:135-41. doi: 10.1016/j.ejmech.2015.01.048. Epub 2015 Jan 24. PMID: 25666913. 3: Madanes AE, Farber M. Danazol. Ann Intern Med. 1982 May;96(5):625-30. doi: 10.7326/0003-4819-96-5-625. PMID: 7041729. 4: TOLKSDORF S, BATTIN ML, CASSIDY JW, MACLEOD RM, WARREN FH, PERLMAN PL. Adrenocortical properties of delta1, 4-pregnadiene-17alpha, 21-diol-3, 11, 20-trione (meticorten) and delta1, 4-pregnadiene-11beta, 17alpha, 21-triol-3, 20-dione (meticortelone). Proc Soc Exp Biol Med. 1956 May;92(1):207-14. doi: 10.3181/00379727-92-22429. PMID: 13336118. 5: Xu SW, Xu Q, Fa YH. [Studies on the production of 16 beta-methyl-11 alpha,17 alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione from 16 beta-methyl-17 alpha,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate by Absidia]. Sheng Wu Gong Cheng Xue Bao. 2000 Jul;16(4):482-4. Chinese. PMID: 11051824. 6: Kolb KH, Latza R, Hepp-Latza O, Lücker PW, Rindt W, Simon B. Human- pharmakokinetische Untersuchungen zur Penetrationskinetik eines 6 alpha-Fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadien-11 beta- dihydroxy-3,20-dion-21-trimethylacetat (Clocortolon-trimethylacetat) nach epikutaner Applikation [Human-pharmacokinetic Studies on Penetration Kinetics of a 6 alpha-Fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadiene-11 beta- dihydroxy-3,20-dione-21-trimethyl-acetic acid (Clocortolone Trimethyl-acetic acid) after e picutaneous application]. Arzneimittelforschung. 1978;28(9):1648-51. German. PMID: 582571. 7: Ko D, Heiman AS, Chen M, Lee HJ. New steroidal anti-inflammatory antedrugs: methyl 21-desoxy-21-chloro-11beta,17alpha-dihydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, methyl 21-desoxy-21-chloro-11beta- hydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, and their 9alpha-fluoro derivatives*. Steroids. 2000 Apr;65(4):210-8. doi: 10.1016/s0039-128x(99)00103-8. PMID: 10713309. 8: MAFFII G, VIRGA R. Attività biologica del 9alpha-fluoro-prednisolone (9alpha- fluoro-delta1-4 pregnadien 11beta-17alpha-21 triidrossi-3,20 dione) [Biological activity of fludrocortisone (9alpha-fluoro-delta1,4-pregnadiene-11beta,17alpha, 21-trihydroxy-3,20-dione)]. Farmaco Sci. 1956;11(10):838-54. Italian. PMID: 13414854. 9: Chalmers JA. Danazol in the treatment of endometriosis. Drugs. 1980 May;19(5):331-41. doi: 10.2165/00003495-198019050-00002. PMID: 6993180. 10: CASPI E, PECHET MM. The metabolism of 1-dehydro-steroids in man: isolation of 6 urinary products following the administration of 11beta, 17alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20-dione. Arch Biochem Biophys. 1957 May;68(1):236-7. doi: 10.1016/0003-9861(57)90346-6. PMID: 13435914. 11: BEYLER AL, NEUMANN ED, BURNHAM DF. The biological activity of a new DCA derivative delta1, 4-pregnadiene-21-ol-3, 20-dione, 3-acetate. Endocrinology. 1956 Apr;58(4):471-6. doi: 10.1210/endo-58-4-471b. PMID: 13305540. 12: Barbieri RL. Danazol. Ann Intern Med. 1982 Aug;97(2):286. doi: 10.7326/0003-4819-97-2-286_1. PMID: 7103299. 13: TOTH J, TUBA Z, SZPORNY L. Amino-derivatives of 11 beta, 17 alpha, 21-trihydroxy-3,20-dioxo-1,4-pregnadiene. Nature. 1961 Aug 5;191:607. doi: 10.1038/191607a0. PMID: 13777665. 14: Mitsukuchi M, Ikemoto T, Taguchi M, Higuchi S, Abe S, Yasui H, Hatayama K, Sota K. Studies on topical antiinflammatory agents. III. Synthesis of 17 alpha- acyloxy-9 alpha-fluoro-11 beta-hydroxy-16 beta-methyl-1,4-pregnadiene-3,20-dione 21-thio derivatives and related compounds. Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3286-93. doi: 10.1248/cpb.37.3286. PMID: 2632073. 15: Potts GO, Schane HP, Edelson J. Pharmacology and pharmacokinetics of danazol. Drugs. 1980 May;19(5):321-30. doi: 10.2165/00003495-198019050-00001. PMID: 6993179. 16: Raizman M. Corticosteroid therapy of eye disease. Fifty years later. Arch Ophthalmol. 1996 Aug;114(8):1000-1. doi: 10.1001/archopht.1996.01100140208016. PMID: 8694704. 17: Hosea SW, Frank MM. Danazole in the treatment of hereditary angioedema. Drugs. 1980 May;19(5):370-2. doi: 10.2165/00003495-198019050-00007. PMID: 6993183. 18: VERMEULEN A. Studies on the metabolism of prednisone. I. Isolation of prednisone, prednisolone, and delta 1-4 pregnadiene-3-11 dione-17alpha-20beta-21-triol from the urine of patients treated with prednisone. Acta Endocrinol (Copenh). 1956 Oct;23(2):113-9. PMID: 13372153. 19: VERMEULEN A. Isolation of delta 1, 4-pregnadiene-3-20-dione-11beta-17alpha-21-triol from the urine of patients treated with metacortandracin. J Clin Endocrinol Metab. 1956 Jan;16(1):163-4. doi: 10.1210/jcem-16-1-163. PMID: 13278394. 20: Greenblatt B, Ben-Nun I. Danazol in the treatment of mammary dysplasia. Drugs. 1980 May;19(5):349-55. doi: 10.2165/00003495-198019050-00004. PMID: 6993181.