GR-65630 | CAS# 117186-80-8 | Biochemical

MedKoo Cat#: 575963 | Name: GR-65630

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GR-65630 is a 5-HT3 serotonin receptor ligand. [3H]GR65630 has been shown to label 5-HT3 receptors in homogenates of rat entorhinal cortex. Note: This product listed here is not radiolabelled [3H]GR65630. We only supply non-radiolabelled version of GR65630.

Chemical Structure

GR-65630

CAS#117186-80-8

Theoretical Analysis

MedKoo Cat#: 575963

Name: GR-65630

CAS#: 117186-80-8

Chemical Formula: C16H17N3O

Exact Mass: 267.1372

Molecular Weight: 267.33

Elemental Analysis: C, 71.89; H, 6.41; N, 15.72; O, 5.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GR 65630; GR65630; GR-65630;

IUPAC/Chemical Name

1-Propanone, 3-(5-methyl-1H-imidazol-4-yl)-1-(1-methyl-1H-indol-2-yl)-

InChi Key

AQCBJPZFJDPIGL-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H17N3O/c1-11-13(18-10-17-11)7-8-16(20)15-9-12-5-3-4-6-14(12)19(15)2/h3-6,9-10H,7-8H2,1-2H3,(H,17,18)

SMILES Code

Cc1nc[nH]c1CCC(=O)c2cc3ccccc3n2C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

L-3,4-dihydroxyphenylalanine (l-DOPA) is the mainstay treatment for Parkinson's disease, but its effectiveness during early disease is marred by the eventual development of l-DOPA induced dyskinesia. In hemi-parkinsonian rats, the serotonin type 3 (5-HT3) antagonists ondansetron and granisetron alleviated dyskinesia induced by l-DOPA without impeding its anti-parkinsonian action; in parkinsonian marmosets, ondansetron alleviated dyskinesia and enhanced l-DOPA anti-parkinsonian action.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 267.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013 May;25(5):439-47, e302. doi: 10.1111/nmo.12107. Epub 2013 Mar 12. PMID: 23490018. 5: Baptista-Hon DT, Deeb TZ, Othman NA, Sharp D, Hales TG. The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine. Br J Pharmacol. 2012 Feb;165(3):693-704. doi: 10.1111/j.1476-5381.2011.01582.x. PMID: 21740409; PMCID: PMC3315041. 6: Nothdurfter C, Tanasic S, Rammes G, Rupprecht R. Modulation of ligand-gated ion channels as a novel pharmacological principle. Pharmacopsychiatry. 2011 May;44 Suppl 1:S27-34. doi: 10.1055/s-0031-1271704. Epub 2011 May 4. PMID: 21544743. 7: Heimes K, Hauk F, Verspohl EJ. Mode of action of peppermint oil and (-)-menthol with respect to 5-HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum. 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