GMC-1111 dihydrochloride | CAS# 254885-69-3 | Dopamine partial agonist

MedKoo Cat#: 575928 | Name: GMC-1111 dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GMC-1111 dihydrochloride is a dopamine partial agonist and stabilizer.

Chemical Structure

GMC-1111 dihydrochloride

CAS#254885-69-3

Theoretical Analysis

MedKoo Cat#: 575928

Name: GMC-1111 dihydrochloride

CAS#: 254885-69-3

Chemical Formula: C16H25Cl2N3S

Exact Mass: 361.1146

Molecular Weight: 362.36

Elemental Analysis: C, 53.03; H, 6.95; Cl, 19.57; N, 11.60; S, 8.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GMC-1111 dihydrochloride; GMC1111 dihydrochloride; GMC 1111 dihydrochloride; GMC-1111 2HCl

IUPAC/Chemical Name

5H-Indeno(5,6-d)thiazole-2,6-diamine, 6,7-dihydro-N6,N6-dipropyl-, dihydrochloride

InChi Key

ZNHLCGFCYLKGOA-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H23N3S.2ClH/c1-3-5-19(6-4-2)13-7-11-9-14-15(10-12(11)8-13)20-16(17)18-14;;/h9-10,13H,3-8H2,1-2H3,(H2,17,18);2*1H

SMILES Code

Cl.Cl.CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 362.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Klintenberg R, Arts J, Jongsma M, Wikström H, Gunne L, Andrén PE. Motor effects of a dopamine stabilizer (GMC1111) in primate models of Parkinson and hemiparkinsonism. Eur J Pharmacol. 2003 Jan 17;459(2-3):231-7. doi: 10.1016/s0014-2999(02)02817-0. PMID: 12524151. 2. van Vliet LA, Rodenhuis N, Wikström H, Pugsley TA, Serpa KA, Meltzer LT, Heffner TG, Wise LD, Lajiness ME, Huff RM, Svensson K, Haenen GR, Bast A. Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. J Med Chem. 2000 Sep 21;43(19):3549-57. doi: 10.1021/jm000087z. PMID: 11000009.