MedKoo Cat#: 413097 | Name: Clocortolone acetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clocortolone acetate is a Glucocorticoid

Chemical Structure

Clocortolone acetate
Clocortolone acetate
CAS#4258-85-9 (acetate)

Theoretical Analysis

MedKoo Cat#: 413097

Name: Clocortolone acetate

CAS#: 4258-85-9 (acetate)

Chemical Formula: C24H30ClFO5

Exact Mass: 452.1766

Molecular Weight: 452.95

Elemental Analysis: C, 63.64; H, 6.68; Cl, 7.83; F, 4.19; O, 17.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Clocortolone acetate; SH818; SH-818; SH 818; Clocortolone 21-acetate
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6 alpha,11 beta, 16 alpha)-
InChi Key
ARPLCFGLEYFDCN-CDACMRRYSA-N
InChi Code
InChI=1S/C24H30ClFO5/c1-12-7-15-16-9-18(26)17-8-14(28)5-6-23(17,4)24(16,25)20(30)10-22(15,3)21(12)19(29)11-31-13(2)27/h5-6,8,12,15-16,18,20-21,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,20+,21-,22+,23+,24+/m1/s1
SMILES Code
C[C@@]12[C@@H](C(COC(C)=O)=O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 452.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Clocortolone Pivalate. 2018 Dec 3. PMID: 29999716. 2: Kircik LH. Clocortolone pivalate: a topical corticosteroid with a unique structure. J Drugs Dermatol. 2013 Feb;12(2):s3-4. PMID: 23377404. 3: Drugs for atopic dermatitis. Med Lett Drugs Ther. 2020 Jun 15;62(1600):89-96. PMID: 32555122. 4: Torok HM, Maas-Irslinger R, Slayton RM. Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. Cutis. 2003 Aug;72(2):161-6. PMID: 12953943. 5: Rosenthal AL. Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. Cutis. 1980 Jan;25(1):96-8. PMID: 6986236. 6: Xu W, Jia X, Liu W, Zhang X, Chen Y, Zhou L, You S. Identification and characterization of three impurities in clocortolone pivalate. J Pharm Biomed Anal. 2012 Mar 25;62:167-71. doi: 10.1016/j.jpba.2011.11.021. Epub 2011 Dec 8. PMID: 22264563. 7: Del Rosso JQ, Kircik L. A Comprehensive Review of Clocortolone Pivalate 0.1% Cream: Structural Development, Formulation Characteristics, and Studies Supporting Treatment of Corticosteroid-responsive Dermatoses. J Clin Aesthet Dermatol. 2012 Jul;5(7):20-4. PMID: 22798972; PMCID: PMC3396454. 8: Mackey JP. Clocortolone, a new topical steroid in dermatoses. J Ir Med Assoc. 1973 Mar 24;66(6):157-9. PMID: 4693153. 9: Singh S, Mann BK. Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review. Clin Cosmet Investig Dermatol. 2012;5:61-8. doi: 10.2147/CCID.S23227. Epub 2012 Jun 22. PMID: 22791998; PMCID: PMC3393117. 10: Del Rosso JQ, Kircik LH. The role of a midpotency topical corticosteroid and the clinical relevance of formulation characteristics in the management of commonly encountered eczematous and inflammatory dermatoses in adults and children: focus on the pharmacologic properties of clocortolone pivalate 0.1% cream. J Drugs Dermatol. 2013 Feb;12(2):s5-s10. PMID: 23377405.