LY-2599506 | CAS# 745051-65-4 | Biochemical

MedKoo Cat#: 575880 | Name: LY-2599506

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-2599506 is a novel glucokinase activator.

Chemical Structure

LY-2599506

CAS#745051-65-4

Theoretical Analysis

MedKoo Cat#: 575880

Name: LY-2599506

CAS#: 745051-65-4

Chemical Formula: C21H25N3O4S

Exact Mass: 415.1566

Molecular Weight: 415.51

Elemental Analysis: C, 60.70; H, 6.06; N, 10.11; O, 15.40; S, 7.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Gka (R)-1; Glucokinase activator (gka) (R)-1; LY-2599506; LY 2599506; LY2599506

IUPAC/Chemical Name

(R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(pyrazin-2-yl)-3-(tetrahydropyran-4-yl)propionamide

InChi Key

DQIITKNITDKAJZ-LJQANCHMSA-N

InChi Code

InChI=1S/C21H25N3O4S/c25-21(24-20-14-22-9-10-23-20)19(13-15-7-11-28-12-8-15)16-1-3-17(4-2-16)29(26,27)18-5-6-18/h1-4,9-10,14-15,18-19H,5-8,11-13H2,(H,23,24,25)/t19-/m1/s1

SMILES Code

O=C(Nc1cnccn1)[C@H](CC2CCOCC2)c3ccc(cc3)S(=O)(=O)C4CC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhang X, Schneck K, Bue-Valleskey J, Yeo KP, Heathman M, Sinha V. Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator. J Pharmacokinet Pharmacodyn. 2013 Feb;40(1):53-65. doi: 10.1007/s10928-012-9286-9. Epub 2012 Dec 22. PMID: 23263772. 2. Schneck KB, Zhang X, Bauer R, Karlsson MO, Sinha VP. Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model. J Pharmacokinet Pharmacodyn. 2013 Feb;40(1):67-80. doi: 10.1007/s10928-012-9287-8. Epub 2012 Dec 22. PMID: 23263773.