Synonym
GK-128 HCl; GK-128 hydrochloride; GK-128 monohydrochloride
IUPAC/Chemical Name
1H-Naphtho(2,1-b)thiopyran-1-one, 2-((2-methyl-1H-imidazol-1-yl)methyl)-, monohydrochloride
InChi Key
DBXKJORICFHAQA-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14N2OS.ClH/c1-12-19-8-9-20(12)10-14-11-22-16-7-6-13-4-2-3-5-15(13)17(16)18(14)21;/h2-9,11H,10H2,1H3;1H
SMILES Code
Cl.Cc1nccn1CC2=CSc3ccc4ccccc4c3C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
342.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Ito C, Isobe Y, Kijima H, Kiuchi Y, Ohtsuki H, Kawamura R, Tsuchida K, Higuchi S. The anti-emetic activity of GK-128 in Suncus murinus. Eur J Pharmacol. 1995 Oct 4;285(1):37-43. doi: 10.1016/0014-2999(95)00372-r. PMID: 8846809.
2. Ito S, Kobayashi Y, Nishimura M, Matsumoto K, Itai S, Yamamoto K. Effect of pulverization on dehydration behavior of crystals of GK-128, a serotonin3 receptor antagonist. J Pharm Sci. 1996 Oct;85(10):1117-22. doi: 10.1021/js9600383. PMID: 8897282.
3. Ito C, Kawamura R, Isobe Y, Tsuchida K, Muramatsu M, Higuchi S. Effect of a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, GK-128, on 5-HT3 receptors mediating contractions and relaxations in guinea-pig distal colon. Gen Pharmacol. 1997 Sep;29(3):353-9. doi: 10.1016/s0306-3623(96)00486-7. PMID: 9378239.
