Synonym
Clemeprol; BRL14342; BRL-14342; BRL 14342
IUPAC/Chemical Name
m-Chloro-alpha-((dimethylamino)methyl)-beta-phenylphenetyl alcohol
InChi Key
KGSABFQIAANNPS-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20ClNO/c1-19(2)12-16(20)17(13-7-4-3-5-8-13)14-9-6-10-15(18)11-14/h3-11,16-17,20H,12H2,1-2H3
SMILES Code
CN(CC(O)C(C1=CC=CC=C1)C2=CC=CC(Cl)=C2)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
289.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Clark MS, Johnson AM, McClelland GR, Nelson DR. Pharmacological and biochemical properties of BRL 14342, a novel potential antidepressant drug. Neuropharmacology. 1980 Dec;19(12):1207-8. doi: 10.1016/0028-3908(80)90203-8. PMID: 7442949.
2: Clark JA, Clark MS, Gardner DV, Gaster LM, Hadley MS, Miller D, Shah A. Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents. J Med Chem. 1979 Nov;22(11):1373-9. doi: 10.1021/jm00197a018. PMID: 533885.
3: Theodorou AE, Katona CL, Davies SL, Hale AS, Kerry SM, Horton RW, Kelly JS, Paykel ES. 3H-imipramine binding to freshly prepared platelet membranes in depression. Psychiatry Res. 1989 Jul;29(1):87-103. doi: 10.1016/0165-1781(89)90189-3. PMID: 2549556.
