MedKoo Cat#: 574666 | Name: Dihydroberberine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydroberberine is a derivative of Berberine -- an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2).

Chemical Structure

Dihydroberberine
CAS#483-15-8

Theoretical Analysis

MedKoo Cat#: 574666

Name: Dihydroberberine

CAS#: 483-15-8

Chemical Formula: C20H19NO4

Exact Mass: 337.1314

Molecular Weight: 337.37

Elemental Analysis: C, 71.20; H, 5.68; N, 4.15; O, 18.97

Price and Availability

Size Price Availability Quantity
5mg USD 320.00 2 Weeks
10mg USD 550.00 2 Weeks
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Related CAS #
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Synonym
Dihydroberberine; Dihydroberberine; Dihydroumbellatine; NSC 331264
IUPAC/Chemical Name
13,13a-Didehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbine
InChi Key
FZAGOOYMTPGPGF-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
SMILES Code
COC1=C(OC)C(CN2CCC3=CC4=C(OCO4)C=C3C2=C5)=C5C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Dai B, Ma Y, Wang W, et al. Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators. J Cell Mol Med. 2017;21(10):2573-2585. doi:10.1111/jcmm.13178 2. Yu D, Lv L, Fang L, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017;12(8):e0181823. Published 2017 Aug 1. doi:10.1371/journal.pone.0181823