MedKoo Cat#: 463904 | Name: BA-1049

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BA-1049 is a selective ROCK2 inhibitor.

Chemical Structure

BA-1049
BA-1049
CAS#1973494-16-4 (R-isomer)

Theoretical Analysis

MedKoo Cat#: 463904

Name: BA-1049

CAS#: 1973494-16-4 (R-isomer)

Chemical Formula: C16H21N3O2S

Exact Mass: 319.1354

Molecular Weight: 319.42

Elemental Analysis: C, 60.16; H, 6.63; N, 13.16; O, 10.02; S, 10.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1973494-16-4 (R-isomer) 2146097-17-6 (S-isomer)
Synonym
BA-1049; BA1049; BA 1049;
IUPAC/Chemical Name
(R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine
InChi Key
MGLIYKZFLDTAMW-GFCCVEGCSA-N
InChi Code
InChI=1S/C16H21N3O2S/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16/h2-5,8,11-13H,6-7,9-10,17H2,1H3/t12-/m1/s1
SMILES Code
O=S(C1=CC=CC2=CN=CC=C21)(N3CCC([C@@H](C)N)CC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. PMID: 31446620; PMCID: PMC7036327. 2: Bond LM, Sellers JR, McKerracher L. Rho kinase as a target for cerebral vascular disorders. Future Med Chem. 2015;7(8):1039-53. doi: 10.4155/fmc.15.45. PMID: 26062400; PMCID: PMC4656981.