Ganciclovir monophosphonate | CAS# 151006-30-3 | Biochemical

MedKoo Cat#: 575812 | Name: Ganciclovir monophosphonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ganciclovir monophosphonate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.

Chemical Structure

Ganciclovir monophosphonate

CAS#151006-30-3 (monophosphonate)

Theoretical Analysis

MedKoo Cat#: 575812

Name: Ganciclovir monophosphonate

CAS#: 151006-30-3 (monophosphonate)

Chemical Formula: C10H16N5O6P

Exact Mass: 333.0838

Molecular Weight: 333.24

Elemental Analysis: C, 36.04; H, 4.84; N, 21.02; O, 28.81; P, 9.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

151006-30-3 (monophosphonate) 86761-38-8 (triphosphate)

Synonym

BW 2482U89; Ganciclovir monophosphonate; SR 3745

IUPAC/Chemical Name

Phosphonic acid, (3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutyl)-, (R)-

InChi Key

QVNXYSKNFUJRMI-ZCFIWIBFSA-N

InChi Code

InChI=1S/C10H16N5O6P/c11-10-13-8-7(9(17)14-10)12-4-15(8)5-21-6(3-16)1-2-22(18,19)20/h4,6,16H,1-3,5H2,(H2,18,19,20)(H3,11,13,14,17)/t6-/m1/s1

SMILES Code

NC1=NC(=O)c2ncn(CO[C@@H](CO)CCP(=O)(O)O)c2N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 333.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Balfour, H.H., Jr. Management of cytomegalovirus disease with antiviral drugs. Rev.Infect.Dis. 12(Suppl. 7), S849-S860 (1990). 2. Bean, B. Antiviral therapy: Current concepts and practices. Clin.Microbiol.Rev. 5(2), 146-182 (1992). 3. Rasmussen, L., Chen, P.T., Mullenax, J.G., et al. Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons. Antimicrob. Agents Chemother. 26(4), 441-445 (1984). 4. Freitas, V.R., Smee, D.F., Chernow, M., et al. Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses. Antimicrob. Agents Chemother. 28(2), 240-245 (1985).