Synonym
HN 11500; HN-11500; HN11500
IUPAC/Chemical Name
2-((5-(2-(phenylsulfonamido)ethyl)thiophen-2-yl)oxy)acetic acid
InChi Key
ISSKMEQROMFEHL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15NO5S2/c16-13(17)10-20-14-7-6-11(21-14)8-9-15-22(18,19)12-4-2-1-3-5-12/h1-7,15H,8-10H2,(H,16,17)
SMILES Code
OC(COc1sc(CCNS(=O)(c2ccccc2)=O)cc1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
341.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Roald HE, Barstad RM, Engen A, Kierulf P, Skjørten F, Sakariassen KS. HN-11500--a novel thromboxane A2 receptor antagonist with antithrombotic activity in humans at arterial blood flow conditions. Thromb Haemost. 1994 Jan;71(1):103-9. PMID: 8165627.
2: Krupiński K, Ferber H, Breddin HK, Bielawiec M. The antithrombotic effect of thromboxane receptor antagonist HN 11500 on thrombus formation in laser thrombosis model and platelet function tests. Acta Haematol Pol. 1994;25(3):235-42. PMID: 7992596.
3: Schenk JF, Radziwon P, Fellier H, Breddin HK. Antiplatelet and anticoagulant effects of "HN-11 500," a selective thromboxane receptor antagonist. Thromb Res. 2001 Jul 15;103(2):79-91. doi: 10.1016/s0049-3848(01)00276-6. PMID: 11457465.
4: Ostensen J, Hede R, Myreng Y, Ege T, Holtz E. Intravenous injection of Albunex microspheres causes thromboxane mediated pulmonary hypertension in pigs, but not in monkeys or rabbits. Acta Physiol Scand. 1992 Mar;144(3):307-15. doi: 10.1111/j.1748-1716.1992.tb09299.x. PMID: 1533987.
5: Giedrojć J, Bielawiec M, Jaromin J, Breddin HK. Effects of combinations of a molsidomin with different antithrombotic drugs in laser-induced thrombosis. Mater Med Pol. 1993 Jul-Dec;25(3-4):153-7. PMID: 8072321.
