Rodatristat ethyl, also known as KAR-5585 and RVT 1201, is a prodrug for rodatristat and a potent, peripheral inhibitor of TPH1. Rodatristat ethyl has demonstrated efficacy in monocrotaline and SUGEN hypoxia nonclinical models of PAH and robust dose-dependent reductions of 5-hydroxyindoleacetic acid, the major metabolite of serotonin in plasma and urine of healthy human subjects.
MedKoo Cat#: 463643
Name: Rodatristat ethyl
CAS#: 1673571-51-1
Chemical Formula: C29H31ClF3N5O3
Exact Mass: 589.2068
Molecular Weight: 590.04
Elemental Analysis: C, 59.03; H, 5.30; Cl, 6.01; F, 9.66; N, 11.87; O, 8.13
The following data is based on the product molecular weight 590.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |