Synonym
Triflocin; CL65,562; CL-65,562; CL 65,562
IUPAC/Chemical Name
3-Pyridinecarboxylic acid, 4-((3-(trifluoromethyl)phenyl)amino)-
InChi Key
NLBIKXOJCISNQP-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H9F3N2O2/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20/h1-7H,(H,17,18)(H,19,20)
SMILES Code
O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CN=C1)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
282.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wright FS, Schnermann J. Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyanide. J Clin Invest. 1974 Jun;53(6):1695-708. doi: 10.1172/JCI107721. PMID: 4830232; PMCID: PMC302666.
2: Belachgar F, Hulin P, Anagnostopoulos T, Planelles G. Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule. Br J Pharmacol. 1994 Jun;112(2):465-70. doi: 10.1111/j.1476-5381.1994.tb13096.x. PMID: 8075865; PMCID: PMC1910392.
3: Gussin RZ, Ronsberg MA. The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog. Proc Soc Exp Biol Med. 1969 Sep;131(4):1258-62. doi: 10.3181/00379727-131-34082. PMID: 5811985.
4: Couloigner V, Teixeira M, Hulin P, Sterkers O, Bichara M, Escoubet B, Planelles G, Ferrary E. Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1695-700. doi: 10.1152/ajpregu.2000.279.5.R1695. PMID: 11049851.
5: Téllez R, Navarrete R, Vásquez A, Díes F, Peña JC. The effect of triflocin, a new diuretic drug, on the renal concentrating mechanism. Rev Invest Clin. 1972 Oct-Dec;24(4):373-88. PMID: 4658743.
6: Kauker ML. Micropuncture study of the effect of triflocin on tubular reabsorption in rats. J Pharmacol Exp Ther. 1973 Feb;184(2):472-80. PMID: 4688182.
7: Del Castillo JR, Marín R, Proverbio T, Proverbio F. Partial characterization of the ouabain-insensitive, Na+-stimulated ATPase activity of kidney basal- lateral plasma membranes. Biochim Biophys Acta. 1982 Oct 22;692(1):61-8. doi: 10.1016/0005-2736(82)90502-8. PMID: 6128997.
8: Dunn MJ. Ouabain-uninhibited Na+ Transport in human erythrocytes: the effects of triflocin. Biochim Biophys Acta. 1972 Feb 11;255(2):567-71. doi: 10.1016/0005-2736(72)90160-5. PMID: 5057934.
9: Agus ZS, Goldberg M. Renal mechanisms of the natriuretic and antiphosphaturic effects of triflocin--a new diuretic. J Lab Clin Med. 1970 Aug;76(2):280-92. PMID: 5434007.
10: Lockhart EA, Dirks JH, Carrière S. Effects of triflocin on renal tubular reabsorption and blood flow distribution. Am J Physiol. 1972 Jul;223(1):89-96. doi: 10.1152/ajplegacy.1972.223.1.89. PMID: 5039079.
