Synonym
CL 115574; CL115574; CL-115574; CL115,574; CL-115,574; CL 115,574
IUPAC/Chemical Name
Prost-13-ene-1,9-dione, 11,16-dihydroxy-1-(hydroxymethyl)-16-methyl-, (11alpha,13E)-(+-)-
InChi Key
KZRFFIVMBRBAAB-CFZYSXGVSA-N
InChi Code
InChI=1S/C22H38O5/c1-3-4-13-22(2,27)14-9-12-19-18(20(25)15-21(19)26)11-8-6-5-7-10-17(24)16-23/h9,12,18-19,21,23,26-27H,3-8,10-11,13-16H2,1-2H3/b12-9+/t18-,19-,21-,22?/m1/s1
SMILES Code
CCCCC(C)(O)C/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(CO)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
382.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lai FM, Tanikella TK, Herzlinger H, Shepherd C, Cervoni P. Effects of CL 115,347, (+/-)-15-deoxy-16-hydroxy-16-vinyl-PGE2 methyl ester, on cardiovascular responses and plasma catecholamines in pithed stroke-prone spontaneously hypertensive rats during sympathetic stimulation. Prostaglandins. 1984 Feb;27(2):273-84. doi: 10.1016/0090-6980(84)90079-0. PMID: 6585870.
2: Wilson DE, Scruggs W, Birnbaum JE. A new prostaglandin E1 analogue (CL-115,574) II. Effects on gastric acid secretion in the dog. Prostaglandins. 1981 Dec;22(6):971-8. doi: 10.1016/0090-6980(81)90025-3. PMID: 7335873.
3: Wilson DE, Levendoglu H, Adams A, Ramsamooj E. A new PGE1 analogue (CL115,574) III. Effects on gastric acid and mucus secretion in man. Prostaglandins. 1984 Jul;28(1):5-11. doi: 10.1016/0090-6980(84)90109-6. PMID: 6484216.
4: Kramer AW Jr, Dougherty WJ, Belson AR, Iatropoulos MJ. Morphologic changes in the gastric mucosa of rats and dogs treated with an analog of prostaglandin E1. Toxicol Pathol. 1985;13(1):26-35. doi: 10.1177/019262338501300105. PMID: 4035261.
5: Birnbaum JE, Wilson DE, Partridge R, Scruggs W, Sloboda AE, Mourillon S. A new prostaglandin E1 analogue (CL115,574). I. antisecretory and cytoprotective effects in the rat. Prostaglandins. 1981 Dec;22(6):957-70. doi: 10.1016/0090-6980(81)90024-1. PMID: 7199752.
