MedKoo Cat#: 412992 | Name: Cks 17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cks 17 is a 16-amino acid protein; has been synthesized; homologous to the first 16 amino acids of the P15E region of HTLV I & II & HIV.

Chemical Structure

Cks 17
Cks 17
CAS#99273-04-8

Theoretical Analysis

MedKoo Cat#: 412992

Name: Cks 17

CAS#: 99273-04-8

Chemical Formula: C87H148N26O24

Exact Mass: 1941.1160

Molecular Weight: 1942.29

Elemental Analysis: C, 53.80; H, 7.68; N, 18.75; O, 19.77

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Synonym
Cks 17; Cks17; Cks-17; Cks-17 peptide
IUPAC/Chemical Name
L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-alpha-glutamylglycylglycyl-
InChi Key
RESSROXEVCGJLA-DFNTYYFDSA-N
InChi Code
InChI=1S/C87H148N26O24/c1-44(2)32-51(89)72(123)103-56(25-27-65(90)114)77(128)112-62(39-66(91)115)83(134)106-54(24-19-31-97-87(94)95)76(127)104-52(23-18-30-96-86(92)93)73(124)100-43-69(118)101-57(33-45(3)4)78(129)113-63(40-71(121)122)84(135)110-59(35-47(7)8)80(131)108-60(36-48(9)10)81(132)111-61(38-50-20-14-13-15-21-50)82(133)109-58(34-46(5)6)79(130)105-53(22-16-17-29-88)75(126)107-55(26-28-70(119)120)74(125)99-41-67(116)98-42-68(117)102-64(85(136)137)37-49(11)12/h13-15,20-21,44-49,51-64H,16-19,22-43,88-89H2,1-12H3,(H2,90,114)(H2,91,115)(H,98,116)(H,99,125)(H,100,124)(H,101,118)(H,102,117)(H,103,123)(H,104,127)(H,105,130)(H,106,134)(H,107,126)(H,108,131)(H,109,133)(H,110,135)(H,111,132)(H,112,128)(H,113,129)(H,119,120)(H,121,122)(H,136,137)(H4,92,93,96)(H4,94,95,97)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)NC(CNC(CNC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,942.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nelson M, Nelson DS, Cianciolo GJ, Snyderman R. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother. 1989;30(2):113-8. doi: 10.1007/BF01665962. PMID: 2598177. 2: Huang SS, Huang JS. A pentacosapeptide (CKS-25) homologous to retroviral envelope proteins possesses a transforming growth factor-beta activity. J Biol Chem. 1998 Feb 27;273(9):4815-8. doi: 10.1074/jbc.273.9.4815. PMID: 9478918. 3: Nelson M, Nelson D. Inhibition of interleukin-2 production by tumor cell products and by CKS-17, a synthetic retroviral envelope peptide. Cancer Immunol Immunother. 1990;30(6):331-41. doi: 10.1007/BF01786882. PMID: 2302724. 4: Blinov VM, Krasnov GS, Shargunov AV, Shurdov MA, Zverev VV. [Mechanisms of retroviral immunosuppressive domain-induced immune modulation]. Mol Biol (Mosk). 2013 Sep-Oct;47(5):707-16. Russian. PMID: 25509343. 5: Takahashi A, Day NK, Luangwedchakarn V, Good RA, Haraguchi S. A retroviral- derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. doi: 10.4049/jimmunol.166.11.6771. PMID: 11359835. 6: Fan Tx, Day NK, Luangwedchakarn V, Chang Y, Ikehara S, Lerner DL, Haraguchi S. The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide. Peptides. 2005 Nov;26(11):2165-74. doi: 10.1016/j.peptides.2005.04.009. Epub 2005 Jun 22. PMID: 15978701. 7: Haraguchi S, Liu WT, Cianciolo GJ, Good RA, Day NK. Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes. Cell Immunol. 1992 May;141(2):388-97. doi: 10.1016/0008-8749(92)90157-k. PMID: 1576656. 8: Luangwedchakarn V, Day NK, Hitchcock R, Brown PG, Lerner DL, Rucker RP, Cianciolo GJ, Good RA, Haraguchi S. A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. Peptides. 2003 May;24(5):631-7. doi: 10.1016/s0196-9781(03)00137-2. PMID: 12895647. 9: Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. doi: 10.1007/s12026-007-0039-6. PMID: 18506644. 10: Iyonaga K, Miyajima M, Suga M, Saita N, Ando M. Alterations in cytokeratin expression by the alveolar lining epithelial cells in lung tissues from patients with idiopathic pulmonary fibrosis. J Pathol. 1997 Jun;182(2):217-24. doi: 10.1002/(SICI)1096-9896(199706)182:2<217::AID-PATH833>3.0.CO;2-A. PMID: 9274534.