MedKoo Cat#: 412994 | Name: Cl 13850

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cl 13850 is a biochemical with carbonic anhydrase activity

Chemical Structure

Cl 13850
Cl 13850
CAS#13018-60-5

Theoretical Analysis

MedKoo Cat#: 412994

Name: Cl 13850

CAS#: 13018-60-5

Chemical Formula: C8H14N4O3S2

Exact Mass: 278.0507

Molecular Weight: 278.35

Elemental Analysis: C, 34.52; H, 5.07; N, 20.13; O, 17.24; S, 23.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Cl 13850; Cl13850; Cl-13850
IUPAC/Chemical Name
Acetamide, N-(5-(((1,1-dimethylethyl)amino)sulfonyl)-1,3,4-thiadiazol-2-yl)-
InChi Key
XQSQJQIWDZTQCE-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H14N4O3S2/c1-5(13)9-6-10-11-7(16-6)17(14,15)12-8(2,3)4/h12H,1-4H3,(H,9,10,13)
SMILES Code
CC(NC1=NN=C(S(=O)(NC(C)(C)C)=O)S1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lönnerholm G, Ridderstråle Y. Intracellular distribution of carbonic anhydrase in the rat kidney. Kidney Int. 1980 Feb;17(2):162-74. doi: 10.1038/ki.1980.20. PMID: 6770166. 2: Norby LH, Bethencourt D, Schwartz JH. Dual effect of carbonic anhydrase inhibitors on H+ transport by the turtle bladder. Am J Physiol. 1981 May;240(5):F400-5. doi: 10.1152/ajprenal.1981.240.5.F400. PMID: 7235014. 3: Erlichman JS, Coates EL, Leiter JC. Carbonic anhydrase and CO2 chemoreception in the pulmonate snail Helix aspersa. Respir Physiol. 1994 Sep;98(1):27-41. doi: 10.1016/0034-5687(94)90034-5. PMID: 7817040. 4: Coates EL, Li A, Nattie EE. Widespread sites of brain stem ventilatory chemoreceptors. J Appl Physiol (1985). 1993 Jul;75(1):5-14. doi: 10.1152/jappl.1993.75.1.5. PMID: 8376301. 5: Pierce WM Jr, Lineberry MD, Waite LC. Effect of sulfonamides on the hypercalcemic response to vitamin D. Horm Metab Res. 1982 Dec;14(12):670-3. doi: 10.1055/s-2007-1019113. PMID: 7152482. 6: Hall GE, Kenny AD. Bone resorption induced by parathyroid hormone and dibutyryl cyclic AMP: role of carbonic anhydrase. J Pharmacol Exp Ther. 1986 Sep;238(3):778-82. PMID: 3018220. 7: Nichols FC, Neuman WF. Lactic acid production in mouse calvaria in vitro with and without parathyroid hormone stimulation: lack of acetazolamide effects. Bone. 1987;8(2):105-9. doi: 10.1016/8756-3282(87)90078-0. PMID: 3593606. 8: Hall GE, Kenny AD. Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro. Calcif Tissue Int. 1985 Mar;37(2):134-42. doi: 10.1007/BF02554832. PMID: 3924369. 9: Coates EL, Li AH, Nattie EE. Acetazolamide on the ventral medulla of the cat increases phrenic output and delays the ventilatory response to CO2. J Physiol. 1991 Sep;441:433-51. doi: 10.1113/jphysiol.1991.sp018760. PMID: 1816381; PMCID: PMC1180207.