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MedKoo Cat#: 463845 | Name: Eglin c (60-63)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eglin c (60-63) is a sequence of a peptide that has been studied for its inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin.

Chemical Structure

Eglin c (60-63)
Eglin c (60-63)
CAS#122299-14-3

Theoretical Analysis

MedKoo Cat#: 463845

Name: Eglin c (60-63)

CAS#: 122299-14-3

Chemical Formula: C18H33N5O7

Exact Mass: 431.2380

Molecular Weight: 431.49

Elemental Analysis: C, 50.10; H, 7.71; N, 16.23; O, 25.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Eglin c (60-63); Eglin-c (60-63); Thr-asn-val-val-OH;
IUPAC/Chemical Name
L-threonyl-L-asparaginyl-L-valyl-L-valine
InChi Key
KAMOTFUFDACEHJ-ZZEGJQGJSA-N
InChi Code
InChI=1S/C18H33N5O7/c1-7(2)13(17(28)23-14(8(3)4)18(29)30)22-15(26)10(6-11(19)25)21-16(27)12(20)9(5)24/h7-10,12-14,24H,6,20H2,1-5H3,(H2,19,25)(H,21,27)(H,22,26)(H,23,28)(H,29,30)/t9-,10+,12+,13+,14+/m1/s1
SMILES Code
CC([C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@@H](NC([C@H]([C@H](O)C)N)=O)CC(N)=O)=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tsuboi S, Takeda M, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXX. Synthesis of eglin c (41-49) and eglin c (60-63) and examination of their inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):184-6. doi: 10.1248/cpb.39.184. PMID: 2049802. 2: Tsuboi S, Nakabayashi K, Matsumoto Y, Teno N, Tsuda Y, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXVIII. Synthesis of peptide fragments related to eglin c and studies on the relationship between their structure and effects on human leukocyte elastase, cathepsin G and alpha-chymotrypsin. Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2369-76. doi: 10.1248/cpb.38.2369. PMID: 2285973.