MedKoo Cat#: 408196 | Name: EGFR-IN-11
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EGFR-IN-11, is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI). This compound was first reported in Eur J Med Chem. 2020 Jan 15;186:111888. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

EGFR-IN-11
EGFR-IN-11
CAS#2463200-44-2

Theoretical Analysis

MedKoo Cat#: 408196

Name: EGFR-IN-11

CAS#: 2463200-44-2

Chemical Formula: C29H35N9O2S

Exact Mass: 573.2634

Molecular Weight: 573.72

Elemental Analysis: C, 60.71; H, 6.15; N, 21.97; O, 5.58; S, 5.59

Price and Availability

Size Price Availability Quantity
50mg USD 1,950.00 2 Weeks
100mg USD 2,950.00 2 Weeks
1g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
EGFR-IN-11; EGFR-IN-11; EGFR IN-11; EGFR-IN 11
IUPAC/Chemical Name
(R)-9-(1-(cyclopropylsulfonyl)pyrrolidin-3-yl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine
InChi Key
RNEHWYIFHKBZAW-XMMPIXPASA-N
InChi Code
InChI=1S/C29H35N9O2S/c1-35-15-17-36(18-16-35)23-9-7-22(8-10-23)31-28-30-19-26-27(34-28)38(29(33-26)32-21-5-3-2-4-6-21)24-13-14-37(20-24)41(39,40)25-11-12-25/h2-10,19,24-25H,11-18,20H2,1H3,(H,32,33)(H,30,31,34)/t24-/m1/s1
SMILES Code
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C=N3)N=C(NC5=CC=CC=C5)N4[C@H]6CN(CC6)S(C7CC7)(=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 573.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Lei H, Fan S, Zhang H, Liu YJ, Hei YY, Zhang JJ, Zheng AQ, Xin M, Zhang SQ. Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors. Eur J Med Chem. 2020 Jan 15;186:111888. doi: 10.1016/j.ejmech.2019.111888. Epub 2019 Nov 16. PMID: 31787359.