Furegrelate | CAS# 85666-24-6 | Biochemical

MedKoo Cat#: 575717 | Name: Furegrelate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Furegrelate is a a thromboxane synthase inhibitor.

Chemical Structure

Furegrelate

CAS#85666-24-6 (free acid)

Theoretical Analysis

MedKoo Cat#: 575717

Name: Furegrelate

CAS#: 85666-24-6 (free acid)

Chemical Formula: C15H11NO3

Exact Mass: 253.0739

Molecular Weight: 253.26

Elemental Analysis: C, 71.14; H, 4.38; N, 5.53; O, 18.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

85666-24-6 (free acid) 85666-17-7 (sodium) 87463-91-0 (sodium hydrate)

Synonym

Furegrelate; Furegrelato; Furegarelatum; furegrelatum; U 63557A; U63557A; U-63557A

IUPAC/Chemical Name

2-Benzofurancarboxylic acid, 5-(3-pyridinylmethyl)-

InChi Key

VHWFITPGPFLBGT-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H11NO3/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11/h1-5,7-9H,6H2,(H,17,18)

SMILES Code

OC(=O)c1oc2ccc(Cc3cccnc3)cc2c1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 253.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Hirenallur-S DK, Detweiler ND, Haworth ST, Leming JT, Gordon JB, Rusch NJ. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200. doi: 10.4103/2045-8932.97605. PMID: 22837860; PMCID: PMC3401873. 2. Pestel S, Nath A, Jungermann K, Schieferdecker HL. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. Biochem Pharmacol. 2003 Aug 15;66(4):643-52. doi: 10.1016/s0006-2952(03)00398-8. PMID: 12906929.