MedKoo Cat#: 412978 | Name: Citropeptin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Citropeptin is a cyclic hexadepsipeptide antibiotic that showed antitumor activity against P388 murine leukemia.

Chemical Structure

Citropeptin
Citropeptin
CAS#128554-13-2

Theoretical Analysis

MedKoo Cat#: 412978

Name: Citropeptin

CAS#: 128554-13-2

Chemical Formula: C50H82N8O15

Exact Mass: 1034.5900

Molecular Weight: 1035.25

Elemental Analysis: C, 58.01; H, 7.98; N, 10.82; O, 23.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Citropeptin
IUPAC/Chemical Name
2-(6-((2E,6E)-4,6-dimethyl-5-oxoocta-2,6-dien-2-yl)-2-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)-2-hydroxy-N-(6-hydroxy-19-(1-hydroxyethyl)-10-isobutyl-22-isopropyl-7-(methoxymethyl)-9-methyl-5,8,11,17,20,24-hexaoxodocosahydro-13H,22H-dipyridazino[6,1-f:6',1'-o][1]oxa[4,7,10,13,16]pentaazacyclononadecin-23-yl)propanamide
InChi Key
HHBCEPSFYPJHIF-AIRRWTJMSA-N
InChi Code
InChI=1S/C50H82N8O15/c1-14-28(6)39(60)30(8)24-31(9)41-29(7)19-20-50(69,73-41)49(11,68)48(67)54-38-40(27(4)5)72-47(66)37(32(10)59)53-42(61)33-17-15-21-51-56(33)44(63)35(23-26(2)3)55(12)43(62)36(25-71-13)58(70)45(64)34-18-16-22-52-57(34)46(38)65/h14,24,26-27,29-30,32-38,40-41,51-52,59,68-70H,15-23,25H2,1-13H3,(H,53,61)(H,54,67)/b28-14+,31-24+
SMILES Code
COCC1N(C(C2CCCNN2C(C(C(C(C)C)OC(C(C(O)C)NC(C3CCCNN3C(C(N(C1=O)C)CC(C)C)=O)=O)=O)NC(C(O)(C4(CCC(C(/C(C)=C/C(C(/C(C)=C/C)=O)C)O4)C)O)C)=O)=O)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,035.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hayakawa Y, Nakagawa M, Toda Y, Seto H. A new depsipeptide antibiotic, citropeptin. Agric Biol Chem. 1990 Apr;54(4):1007-11. PMID: 1368544. 2: Nakagawa M, Hayakawa Y, Furihata K, Seto H. Structural studies on new depsipeptide antibiotics, variapeptin and citropeptin. J Antibiot (Tokyo). 1990 May;43(5):477-84. doi: 10.7164/antibiotics.43.477. PMID: 2358400. 3: Nakagawa M, Hayakawa Y, Adachi K, Seto H. A new depsipeptide antibiotic, variapeptin. Agric Biol Chem. 1990 Mar;54(3):791-4. PMID: 1368536. 4: Assem ES, Peh KH, Wan BY, Manaviazar S, Walters MA, George JH, Hale KJ. Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflamm Res. 2008;57 Suppl 1:S21-2. doi: 10.1007/s00011-007-0610-6. PMID: 18345507. 5: Hale KJ, Manaviazar S, Lazarides L, George J, Walters MA, Cai J, Delisser VM, Bhatia GS, Peak SA, Dalby SM, Lefranc A, Chen YN, Wood AW, Crowe P, Erwin P, El- Tanani M. Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb. Org Lett. 2009 Feb 5;11(3):737-40. doi: 10.1021/ol802818f. PMID: 19175352.