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MedKoo Cat#: 130511 | Name: BI-894416

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI-894416 is a novel potent and selective spleen tyrosine kinase inhibitor developed to treat severe asthma.

Chemical Structure

BI-894416
BI-894416
CAS#1810059-82-5

Theoretical Analysis

MedKoo Cat#: 130511

Name: BI-894416

CAS#: 1810059-82-5

Chemical Formula: C20H26N6O2

Exact Mass: 382.2117

Molecular Weight: 382.47

Elemental Analysis: C, 62.81; H, 6.85; N, 21.97; O, 8.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
BI-1342561
Synonym
BI 894416, BI894416
IUPAC/Chemical Name
(R)-4-((R)-1-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)-2-methyl-2H-pyrazolo[3,4-d]pyridin-4-yl)oxy)ethyl)pyrrolidin-2-one
InChi Key
RHKFNBPBFDOJOE-CHWSQXEVSA-N
InChi Code
InChI=1S/C20H26N6O2/c1-12(13-6-18(27)21-8-13)28-19-15-11-25(5)24-17(15)7-16(23-19)14-9-22-26(10-14)20(2,3)4/h7,9-13H,6,8H2,1-5H3,(H,21,27)/t12-,13-/m1/s1
SMILES Code
CN1C=C2C(C=C(C3=CN(C(C)(C)C)N=C3)N=C2O[C@H](C)[C@H]4CNC(C4)=O)=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Latli B, Hrapchak MJ, Samankumara LP, Fandrick DR, Pennino S, Lee H, Song JJ. Synthesis of BI 894416 and BI 1342561, two potent and selective spleen tyrosine kinase inhibitors, labeled with carbon 14 and with deuterium. J Labelled Comp Radiopharm. 2023 Apr-May;66(4-6):155-168. doi: 10.1002/jlcr.4024. Epub 2023 Apr 24. PMID: 37057686.