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MedKoo Cat#: 463809 | Name: CPPQ

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CPPQ is a novel potent 5-hydroxytryptamine type 6 receptor (5-HT6R) neutral antagonist at Gs, not impacting neurite growth (process controlled by Cdk5). MD simulations highlighted receptor conformational changes.

Chemical Structure

CPPQ
CPPQ
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463809

Name: CPPQ

CAS#: unknown

Chemical Formula: C18H20ClN5O2S

Exact Mass: 405.1026

Molecular Weight: 405.90

Elemental Analysis: C, 53.26; H, 4.97; Cl, 8.73; N, 17.25; O, 7.88; S, 7.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CPPQ;
IUPAC/Chemical Name
1-((3-chlorophenyl)sulfonyl)-2-ethyl-4-(piperazin-1-yl)-1H-imidazo[4,5-c]pyridine
InChi Key
GATDTMAYFGZGAV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H20ClN5O2S/c1-2-16-22-17-15(6-7-21-18(17)23-10-8-20-9-11-23)24(16)27(25,26)14-5-3-4-13(19)12-14/h3-7,12,20H,2,8-11H2,1H3
SMILES Code
CCC(N1S(=O)(C2=CC=CC(Cl)=C2)=O)=NC3=C1C=CN=C3N4CCNCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vanda D, Canale V, Chaumont-Dubel S, Kurczab R, Satała G, Koczurkiewicz- Adamczyk P, Krawczyk M, Pietruś W, Blicharz K, Pękala E, Bojarski AJ, Popik P, Marin P, Soural M, Zajdel P. Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States. J Med Chem. 2021 Jan 13. doi: 10.1021/acs.jmedchem.0c02009. Epub ahead of print. PMID: 33439019.