MedKoo Cat#: 591895 | Name: Neoarsphenamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neoarsphenamine is an antisyphilitic agent still used occasionally for infections.

Chemical Structure

Neoarsphenamine
Neoarsphenamine
CAS#457-60-3

Theoretical Analysis

MedKoo Cat#: 591895

Name: Neoarsphenamine

CAS#: 457-60-3

Chemical Formula: C13H13As2N2NaO4S

Exact Mass: 465.8926

Molecular Weight: 466.15

Elemental Analysis: C, 33.50; H, 2.81; As, 32.14; N, 6.01; Na, 4.93; O, 13.73; S, 6.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Neoarsphenamine; Neo-I.C.I.; Neoarsfenamin
IUPAC/Chemical Name
Sulfoxylic acid, mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydroxyphenyl)amino)methyl) ester, monosodium salt
InChi Key
CXFGBOZIEIIEIH-UHFFFAOYSA-M
InChi Code
InChI=1S/C13H14As2N2O4S.Na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-21-22-20;/h1-6,17-20H,7,16H2;/q;+1/p-1
SMILES Code
[O-]SOCNC1=CC(/[As]=[As]/C2=CC=C(O)C(N)=C2)=CC=C1O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 466.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bernhardt M. Hoffman's drops: the technique of the concentrated neosalvarsan injection. Skinmed. 2015 Jan-Feb;13(1):65. PubMed PMID: 25842475. 2: Heynick F. The original 'magic bullet' is 100 years old - extra. Br J Psychiatry. 2009 Nov;195(5):456. doi: 10.1192/bjp.195.5.456. PubMed PMID: 19880937. 3: Calvo A. [Ehrlich and the "magic bullet" concept]. Rev Esp Quimioter. 2006 Mar;19(1):90-2. Spanish. PubMed PMID: 16688302. 4: Michel JC, de Thoisy B, Contamin H. Chemotherapy of haemobartonellosis in squirrel monkeys (Saimiri sciureus). J Med Primatol. 2000 Apr;29(2):85-7. PubMed PMID: 10950456. 5: Salgado M, Sans M, Forns X, Bruguera M, Castells A, Navasa M, Rodés J. [Hepatic angiosarcoma: a report of a case associated with treatment with arsenic salts and a review of the literature]. Gastroenterol Hepatol. 1995 Mar;18(3):132-5. Review. Spanish. PubMed PMID: 7621289. 6: Clemmesen J. [On the existence of Neosalvarsan]. Ugeskr Laeger. 1993 May 24;155(21):1651-2. Danish. PubMed PMID: 8317006. 7: Hadani A, Guglielmone AA, Anziani OS, Tarablas H, Mangold A, Bermudez A, Castor JC, Gonzalez de Rios L. A case of apparent suppression of Anaplasma marginale infection by eperythrozoonosis (Eperythrozoon teganodes). Vet Parasitol. 1982 Feb;9(3-4):267-72. PubMed PMID: 6211820. 8: Purnell RE, Lewis D, Holman MR, Young ER. Investigations on a Babesia isolated from Scottish sheep. Parasitology. 1981 Oct;83(Pt 2):347-56. PubMed PMID: 7329723. 9: Moulder JE, Lo PS, Fischer JJ. Effect of actinomycin D and neoarsphenamine on tumor control and skin tolerance in the rat. Cancer Treat Rep. 1978 May;62(5):713-9. PubMed PMID: 148967. 10: Kligerman MM, Schulhof L. Sensitization of bacteria to x-ray by neoarsphenamine. Radiat Res. 1969 Sep;39(3):571-9. PubMed PMID: 4896771. 11: Kligerman MM, Löfgren S, Dean C. Sensitization of Micrococcus sodonensis to x radiation by neoarsphenamine in the presence of oxygen. Radiology. 1967 May;88(5):993-4. PubMed PMID: 4225867. 12: Frey JR, de Weck AL, Geleick H. Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. IV. Desensitization to NEO. Int Arch Allergy Appl Immunol. 1966;30(6):521-37. PubMed PMID: 4225359. 13: Frey JR, de Weck AL, Geleick H. Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. 3. Immunological tolerance to NEO. Int Arch Allergy Appl Immunol. 1966;30(5):428-45. PubMed PMID: 4225334. 14: Frey JR, de Weck AL, Geleick H. Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. I. Sensitization to NEO. Overall results and experiments on the skin testing technique. Int Arch Allergy Appl Immunol. 1966;30(3):288-312. PubMed PMID: 4224664. 15: Frey JR, de Weck AL, Geleick H. Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. II. Influence of various factors on sensitization to NEO. Int Arch Allergy Appl Immunol. 1966;30(4):385-404. PubMed PMID: 4224602. 16: SUZUKI T, FUKADA C. THE MECHANISM OF THE SEROTONIN RELEASING ACTION OF CONGO RED AND THE ROLE OF SEROTONIN IN COLLOID SHOCK. Jpn J Pharmacol. 1964 Sep;14:363-74. PubMed PMID: 14265200. 17: TERRIER G. [TOPICAL TREATMENT OF SOME PHARYNGEAL LESIONS WITH NEOARSPHENAMINE (COLLUNOVAR-ATOMISEUR)]. Ther Umsch. 1964 Jul;21:272-4. French. PubMed PMID: 14248098. 18: WINTHER K. ["TICK ENCEPHALITIS", ARBORVIRUS INFECTION OF THE CENTRAL NERVOUS SYSTEM]. Ugeskr Laeger. 1964 Jun 11;126:831-4. Danish. PubMed PMID: 14161923. 19: FREY JR, GELEICK H, DEWECK A. IMMUNOLOGICAL TOLERANCE INDUCED IN ANIMALS PREVIOUSLY SENSITIZED TO SIMPLE CHEMICAL COMPOUNDS. Science. 1964 May 15;144(3620):853-4. PubMed PMID: 14149398. 20: STRAUSS WG, MANWARING JH. SPARGANOSIS. A NEW CASE IN THE UNITED STATES AND REVIEW OF THE LITERATURE. Dermatol Trop Ecol Geogr. 1964 Apr-Jun;28:73-8. PubMed PMID: 14201329.