JAK1-IN-38a | CAS#unknown | JAK1-selective inhibitor

MedKoo Cat#: 463802 | Name: JAK1-IN-38a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JAK1-IN-38a is a novel highly potent JAK1-selective inhibitor, exhibiting excellent selectivity over JAK2, JAK3, and TYK2.

Chemical Structure

JAK1-IN-38a

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463802

Name: JAK1-IN-38a

CAS#: unknown

Chemical Formula: C22H26ClN5O

Exact Mass: 411.1826

Molecular Weight: 411.93

Elemental Analysis: C, 64.15; H, 6.36; Cl, 8.61; N, 17.00; O, 3.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JAK1-IN-38a; JAK1IN-38a; JAK1 IN-38a; JAK1-IN38a; JAK1-IN 38a; JAK1IN38a; JAK1 IN 38a;

IUPAC/Chemical Name

4-(((2S,4S)-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

InChi Key

ZAVSMABHFLBCSH-YOEHRIQHSA-N

InChi Code

InChI=1S/C22H26ClN5O/c1-14-11-17(8-10-28(14)13-15-3-5-16(23)6-4-15)27-20-18-7-9-25-21(18)26-12-19(20)22(29)24-2/h3-7,9,12,14,17H,8,10-11,13H2,1-2H3,(H,24,29)(H2,25,26,27)/t14-,17-/m0/s1

SMILES Code

ClC1=CC=C(CN2CC[C@@H](C[C@@H]2C)NC3=C4C=CNC4=NC=C3C(NC)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Park E, Lee SJ, Moon H, Park J, Jeon H, Hwang JS, Hwang H, Hong KB, Han SH, Choi S, Kang S. Discovery and Biological Evaluation of N-Methyl- pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors. J Med Chem. 2021 Jan 11. doi: 10.1021/acs.jmedchem.0c01026. Epub ahead of print. PMID: 33428419.