Synonym
R 8110; R-8110; R8110;
IUPAC/Chemical Name
ethyl 1-(1-(4-fluorophenyl)ethyl)-1H-imidazole-5-carboxylate hydrochloride
InChi Key
MRUMQONBVRNYPI-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15FN2O2.ClH/c1-3-19-14(18)13-8-16-9-17(13)10(2)11-4-6-12(15)7-5-11;/h4-10H,3H2,1-2H3;1H
SMILES Code
CCOC(c1n(C(c2ccc(F)cc2)C)cnc1)=O.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
298.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: van Dijk P, Degryse AD, Ooms LA, Lagerweij E. R 8110, a new short-acting hypnotic in dogs. Res Vet Sci. 1987 Mar;42(2):200-3. PubMed PMID: 3296064.
2: De Coster R, Wouters W, Beerens D, Haelterman C, Doolaege R, Goeminne N, Krekels M. Comparative effects of etomidate and its fluoro analogue, R 8110 on testicular, adrenal and ovarian steroid biosynthesis. J Vet Pharmacol Ther. 1988 Dec;11(4):345-53. PubMed PMID: 3210261.
3: Monbaliu J, Degryse AD, Ooms LA, Van Dijk P, Lagerweij E, Michiels M, Woestenborghs R, Heykants J. Hypnoanalgesia with R 8110/fentanyl in the dog: pharmacodynamic and pharmacokinetic interactions. J Vet Pharmacol Ther. 1988 Mar;11(1):63-70. PubMed PMID: 3379665.
4: De Coster R, Degryse AD, Van Dijk P, Ooms LA, Lagerweij E. Comparison of the effects of etomidate and its fluoro analogue, R 8110, on plasma cortisol, 11 beta-deoxycortisol, 17 alpha-hydroxyprogesterone and testosterone concentrations in dogs. J Vet Pharmacol Ther. 1987 Sep;10(3):227-32. PubMed PMID: 3656509.
5: van Dijk P, Degryse AD, Ooms L, Lagerweij E. Clinical, cardiovascular and respiratory effects of R8110 in premedicated dogs. J Vet Pharmacol Ther. 1987 Jun;10(2):114-8. PubMed PMID: 3612938.
