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MedKoo Cat#: 412947 | Name: Rosaramicin propionate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rosaramicin propionate is an antibacterial

Chemical Structure

Rosaramicin propionate
Rosaramicin propionate
CAS#51481-64-2 (propionate)

Theoretical Analysis

MedKoo Cat#: 412947

Name: Rosaramicin propionate

CAS#: 51481-64-2 (propionate)

Chemical Formula: C34H55NO10

Exact Mass: 637.3826

Molecular Weight: 637.81

Elemental Analysis: C, 64.03; H, 8.69; N, 2.20; O, 25.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
60802-40-6 (Na+ Phosphate) 55103-30-5 (butyrate) 35834-26-5 (free base) 51481-64-2 (propionate) 51547-64-9 (stearate)
Synonym
Rosaramicin propionate; Sch17894; Sch-17894; Sch 17894
IUPAC/Chemical Name
(2S,3R,4S,6R)-4-(dimethylamino)-2-(((1S,2R,3R,7R,8S,9S,10R,12R,16S,E)-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl propionate
InChi Key
JTJAMAJKINOBDT-FIJHNNTRSA-N
InChi Code
InChI=1S/C34H55NO10/c1-10-27-22(6)32-34(7,45-32)14-12-25(37)19(3)16-23(13-15-36)30(21(5)26(38)18-29(40)42-27)44-33-31(43-28(39)11-2)24(35(8)9)17-20(4)41-33/h12,14-15,19-24,26-27,30-33,38H,10-11,13,16-18H2,1-9H3/b14-12+/t19-,20-,21+,22-,23+,24+,26-,27-,30-,31-,32+,33+,34+/m1/s1
SMILES Code
CC[C@H]1OC(C[C@H]([C@@H]([C@H]([C@H](C[C@H](C(/C=C/[C@@]2(O[C@H]2[C@@H]1C)C)=O)C)CC=O)O[C@@H]3O[C@@H](C[C@H](N(C)C)[C@H]3OC(CC)=O)C)C)O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 637.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nolan CM, Monson TP, Ulmer WC Jr. Rosaramicin versus penicillin G in experimental Pneumococcal meningitis. Antimicrob Agents Chemother. 1979 Dec;16(6):776-80. doi: 10.1128/aac.16.6.776. PMID: 43705; PMCID: PMC352952. 2: Darne JF, Ridgway GL, Oriel JD. Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results. Br J Vener Dis. 1982 Apr;58(2):117-20. doi: 10.1136/sti.58.2.117. PMID: 7039760; PMCID: PMC1046020. 3: Funaishi K, Kawamura K, Satoh F, Hiramatsu M, Hagiwara M, Okanish M. New analogues of rosaramicin isolated from a Micromonospora strain. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. J Antibiot (Tokyo). 1990 Aug;43(8):938-47. doi: 10.7164/antibiotics.43.938. PMID: 2088343. 4: Lin CC, Chung M, Gural R, Schuessler D, Kim HK, Radwanski E, Marco A, DiGiore C, Symchowicz S. Pharmacokinetics and metabolism of rosaramicin in humans. Antimicrob Agents Chemother. 1984 Oct;26(4):522-6. doi: 10.1128/aac.26.4.522. PMID: 6517543; PMCID: PMC179957. 5: Stoehr GP, Juhl RP, Veals J, Symchowicz S, Gural R, Lin C, McDonald RH. The excretion of rosaramicin in breast milk. J Clin Pharmacol. 1985 Mar;25(2):89-94. doi: 10.1002/j.1552-4604.1985.tb02807.x. PMID: 3988965. 6: Baughn RE, Musher DM, Adams CB, Knox JM. Evaluation of rosaramicin phosphate in treatment of experimental syphilis in rabbits. Antimicrob Agents Chemother. 1981 Jan;19(1):117-21. doi: 10.1128/aac.19.1.117. PMID: 7018381; PMCID: PMC181368. 7: Massa T, Davis GJ, Schiavo D, Sinha DP, Szot RJ, Black HE, Schwartz E. Tapetal changes in beagle dogs. II. Ocular changes after intravenous administration of a macrolide antibiotic--rosaramicin. Toxicol Appl Pharmacol. 1984 Feb;72(2):195-200. doi: 10.1016/0041-008x(84)90303-x. PMID: 6695372. 8: Nakajima S, Kojiri K, Morishima H, Okanishi M. New analogs of rosaramicin isolated from a Micromonospora strain. II. Structure determination. J Antibiot (Tokyo). 1990 Aug;43(8):1006-9. doi: 10.7164/antibiotics.43.1006. PMID: 2211347. 9: Siegrist S, Lagouardat J, Moreau N, LeGoffic F. Mechanism of action of a 16-membered macrolide. Binding of rosaramicin to the Escherichia coli ribosome and its subunits. Eur J Biochem. 1981 Apr;115(2):323-7. doi: 10.1111/j.1432-1033.1981.tb05241.x. PMID: 6786880. 10: Ahonkhai VI, Cherubin CE, Sierra MF, Bokkenheuser VD, Shulman MA, Mosenthal AC. In vitro susceptibility of Campylobacter fetus subsp. jejuni to N-formimidoyl thienamycin, rosaramicin, cefoperazone, and other antimicrobial agents. Antimicrob Agents Chemother. 1981 Dec;20(6):850-1. doi: 10.1128/aac.20.6.850. PMID: 6459767; PMCID: PMC181813.