Saquinavir, also known as Ro 31-8959, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. Typically it is used with ritonavir or lopinavir/ritonavir to increase its affect. Saquinavir is a protease inhibitor. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.
MedKoo Cat#: 575628
Name: Saquinavir free base
CAS#: 127779-20-8 (free base)
Chemical Formula: C38H50N6O5
Exact Mass: 670.3843
Molecular Weight: 670.85
Elemental Analysis: C, 68.04; H, 7.51; N, 12.53; O, 11.92
The following data is based on the product molecular weight 670.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
