Synonym
Cinepazet maleate; MD6753; MD-6753; MD 6753
IUPAC/Chemical Name
1-Piperazineacetic acid, 4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, ethyl ester, (Z)-2-butenedioate (1:1)
InChi Key
URWISVHSKBDRKE-GVTSEVKNSA-N
InChi Code
InChI=1S/C20H28N2O6.C4H4O4/c1-5-28-19(24)14-21-8-10-22(11-9-21)18(23)7-6-15-12-16(25-2)20(27-4)17(13-15)26-3;5-3(6)1-2-4(7)8/h6-7,12-13H,5,8-11,14H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-
SMILES Code
O=C(OCC)CN1CCN(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CC1.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
508.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Levy JV. Cinepazet relaxation of aortic strips from normal and spontaneously hypertensive rats. Res Commun Chem Pathol Pharmacol. 1980 Jul;29(1):205-8. PMID: 7403676.
2: Cherchi A, Fonzo R. I calcioantagonisti nella terapia dell'angina pectoris da sforzo [Calcium antagonists in the therapy of angina pectoris of effort]. Boll Soc Ital Cardiol. 1978;(1 Suppl):114-30. Italian. PMID: 395961.
3: Sigel H, Janke J, Fleckenstein A. Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)). Recent Adv Stud Cardiac Struct Metab. 1975;6:121-6. PMID: 1197874.
4: Petralito A, Liuzzo A, Lunetta M, Mangiafico RA, Fiore CE. Calcio-antagonisti e metabolismo glicidico [Calcium antagonists and carbohydrate metabolism]. Boll Soc Ital Cardiol. 1978;23(9):1545-58. Italian. PMID: 553628.
5: Petralito A, Lunetta M, Liuzzo A, Fiore CE, Mangiafico RA. Influenza del maleato di cinepazato d'etile sulla curva da carico di glucosio in soggetti normali e in soggetti con metabolismo glicidico alterato [Influence of maleate of ethyl cinepazate on the curve of the glucose tolerance test in normal subjects and subjects with altered carbohydrate metabolism]. Boll Soc Ital Cardiol. 1979;24(2):177-81. Italian. PMID: 398219.
6: Novo S, Davì G, Riolo F, Pinto A, Avellone G, Fazio M. Valutazione, mediante test ergometrico, degli effetti della nifedipina, del verapamil e del maleato di cinepazato di etile nell'angina da sforzo [The ergometric test in the evaluation of the effects of nifedipine, verapamil and ethyl cinepazat maleate in angina of effort]. Boll Soc Ital Cardiol. 1980;25(2):139-48. Italian. PMID: 7236439.
7: Cherchi A, Fonzo R, Mercuro G, Lai C. Sull'influenza del maleato di cinepazato di etile sul test di tolleranza allo sforzo in pazienti affetti da angina pectoris [Influence of ethyl cinepazate maleate on the exercise tolerance test in patients with angina pectoris]. Boll Soc Ital Cardiol. 1978;23(1):265-80. Italian. PMID: 113021.
