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MedKoo Cat#: 412880 | Name: Cicloprolol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cicloprolol hydrochloride is the salt form of Cicloprolol (free base), a beta-adrenoceptor antagonist.

Chemical Structure

Cicloprolol hydrochloride
Cicloprolol hydrochloride
CAS#63686-79-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 412880

Name: Cicloprolol hydrochloride

CAS#: 63686-79-3 (HCl)

Chemical Formula: C18H30ClNO4

Exact Mass: 359.1863

Molecular Weight: 359.89

Elemental Analysis: C, 60.07; H, 8.40; Cl, 9.85; N, 3.89; O, 17.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
63686-79-3 (HCl) 63659-12-1 (free base)
Synonym
Cicloprolol hydrochloride; SL-D.177; SLD.177; SL D.177
IUPAC/Chemical Name
2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethoxy)phenoxy)-3-((1-methylethyl)amino)-, hydrochloride, (+-)-
InChi Key
IFQJSQQPCCLGLZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H29NO4.ClH/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15;/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3;1H
SMILES Code
OC(CNC(C)C)COC1=CC=C(OCCOCC2CC2)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 359.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hicks PE, Cavero I, Manoury P, Lefevre-Borg F, Langer SZ. Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol. J Pharmacol Exp Ther. 1987 Sep;242(3):1025-34. PMID: 2888869. 2: McCaffrey PM, Burke M, Riddell JG, Shanks RG. Studies of the agonist and antagonist activity of cicloprolol in man. Eur J Clin Pharmacol. 1988;34(6):569-75. doi: 10.1007/BF00615219. PMID: 3169110. 3: Weber S, Kahan A, Pinquier JL, Julien J, Rosenzweig P, Bianchetti G, Morselli PL, Dessault O, De Lauture D, Strauch G. Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects. Br J Clin Pharmacol. 1990 Sep;30(3):411-6. doi: 10.1111/j.1365-2125.1990.tb03792.x. PMID: 1977438; PMCID: PMC1368144. 4: Cocco G, Alfiero R, Pouleur H. An evaluation of the safety of the beta- modulator cicloprolol in chronic heart failure. Clin Cardiol. 1992 Jan;15(1):38-42. doi: 10.1002/clc.4960150109. PMID: 1347258. 5: Hadfield SE, Slee SJ, Snow HM. The cardiovascular pharmacology of xamoterol, cicloprolol, prenalterol and pindolol in the anaesthetised dog. Br J Clin Pharmacol. 1989;28 Suppl 1(Suppl 1):78S-81S. doi: 10.1111/j.1365-2125.1989.tb03580.x. PMID: 2572262; PMCID: PMC1379883. 6: Bonandi L, Metra M, Niccoli L, Ettori F, Nodari S, Dei Cas L, Visioli O. Combined invasive and noninvasive study of left ventricular systolic and diastolic function following acute administration of cicloprolol to subjects with normal cardiac function. Cardiovasc Drugs Ther. 1992 Oct;6(5):513-7. doi: 10.1007/BF00055610. PMID: 1360256. 7: Rigaud M, Hamoir V, Chabanier A, Neveux E, Cazor JL, Bardet J, Bourdarias JP. Effets hémodynamiques au repos et à l'effort d'un nouvel agent bêta-agoniste partiel (cicloprolol) dans l'insuffisance cardiaque modérée [Hemodynamic effects at rest and exertion of a new partial beta-agonist (cicloprolol) in moderated cardiac failure]. Arch Mal Coeur Vaiss. 1988 Oct;81(10):1251-8. French. PMID: 2906233. 8: Silke B, Verma SP, Sharma SK, Frais MA, Reynolds G, Taylor SH. Comparative effects of atenolol and cicloprolol on cardiac performance in coronary heart disease. J Cardiovasc Pharmacol. 1989 Jan;13(1):155-61. PMID: 2468927. 9: Guinebault P, Haddouche A, Bianchetti G. High-performance liquid and gas chromatographic methods for the determination of cicloprolol. J Chromatogr. 1990 Feb 23;525(2):359-67. doi: 10.1016/s0378-4347(00)83412-x. PMID: 1970344. 10: Silke B, Verma SP, Sharma SK, Baig W, Jackson NC, Reynolds G, Frais MA, Taylor SH. Haemodynamic dose-response actions of cicloprolol in left ventricular dysfunction due to ischaemic heart disease. Int J Cardiol. 1987 Nov;17(2):127-36. doi: 10.1016/0167-5273(87)90124-0. PMID: 2890589.

View History

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