SGC-SMARCA-BRDVIII is a selective and high affinity SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomains (Kd(ITC) values are 35, 36 and 13 nM, respectively). SGC-SMARCA-BRDVIII exhibits selectivity over 25 other bromodomain families and shows no off-target activity on 85 protein kinases screened using temperature-shift binding assays. SGC-SMARCA-BRDVIII suppresses formation of 3T3-L1 mouse fibroblasts into adipocytes (EC50 <1.0 μM).
MedKoo Cat#: 463732
Name: SGC-SMARCA-BRDVIII
CAS#: 1997319-84-2
Chemical Formula: C19H25N5O3
Exact Mass: 371.1957
Molecular Weight: 371.44
Elemental Analysis: C, 61.44; H, 6.78; N, 18.85; O, 12.92
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.1 | 100.00 | |
| Ethanol | 3.7 | 10.00 |
The following data is based on the product molecular weight 371.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
