MedKoo Cat#: 412873 | Name: Cyclindole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclindole is an antipsychotic with a tricyclic structure that was never marketed. It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating it acts as a D₂ receptor antagonist.

Chemical Structure

Cyclindole
Cyclindole
CAS#32211-97-5

Theoretical Analysis

MedKoo Cat#: 412873

Name: Cyclindole

CAS#: 32211-97-5

Chemical Formula: C14H18N2

Exact Mass: 214.1470

Molecular Weight: 214.31

Elemental Analysis: C, 78.46; H, 8.47; N, 13.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Cyclindole; Win 27147-2; Ciclindolum; Ciclindol
IUPAC/Chemical Name
1H-Carbazol-3-amine, 2,3,4,9-tetrahydro-N,N-dimethyl-
InChi Key
WZXJEMXDECWINY-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18N2/c1-16(2)10-7-8-14-12(9-10)11-5-3-4-6-13(11)15-14/h3-6,10,15H,7-9H2,1-2H3
SMILES Code
CN(C)C1CCC(NC2=C3C=CC=C2)=C3C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Edelson J, Benziger DP. Disposition of a series of tetrahydrocarbazoles. Drug Metab Rev. 1980;11(2):263-89. doi: 10.3109/03602538008994027. PMID: 7011760. 2: Benziger DP, Balfour K, Clemans S, Edelson J. Absorption, excretion and disposition of cyclindole in laboratory animals and human volunteers. Drug Metab Dispos. 1977 May-Jun;5(3):239-45. PMID: 17521. 3: Bhamidipati RK, Mullangi R, Srinivas NR. Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts. Xenobiotica. 2017 Feb;47(2):112-118. doi: 10.3109/00498254.2016.1166290. Epub 2016 Apr 19. PMID: 27093131. 4: Wood PL, McQuade PS. Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics. Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):773-7. doi: 10.1016/0278-5846(84)90057-5. PMID: 6152347. 5: Nestoros JN, Ban TA, Lehmann HE. WIN 27,147-2 in the treatment of depression. An uncontrolled clinical study. Int Pharmacopsychiatry. 1977;12(2):86-94. doi: 10.1159/000468292. PMID: 19370. 6: Gallant DM, Bishop MP, Guerrero-Figueroa R. WIN 27,147-2: a preliminary evaluation of a potential antidepressant compound: animal and human correlations. Curr Ther Res Clin Exp. 1972 Feb;14(2):61-4. PMID: 4622439.