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MedKoo Cat#: 462608 | Name: BAY1003803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAY1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis.

Chemical Structure

BAY1003803
BAY1003803
CAS#1152781-51-5 (free base)

Theoretical Analysis

MedKoo Cat#: 462608

Name: BAY1003803

CAS#: 1152781-51-5 (free base)

Chemical Formula: C21H18ClF5N2O4

Exact Mass: 492.0875

Molecular Weight: 492.83

Elemental Analysis: C, 51.18; H, 3.68; Cl, 7.19; F, 19.27; N, 5.68; O, 12.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1152781-51-5 (free base) 2205062-61-7 (hydrate) 2204293-93-4 (RS-isomer)
Synonym
BAY1003803; BAY 1003803; BAY-1003803
IUPAC/Chemical Name
5-(((1S,2S)-1-(2-chloro-3-fluoro-4-methoxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-(methoxymethyl)propyl)amino)-7-fluoroquinolin-2(1H)-one
InChi Key
GVVXAENDJXFVQE-XJDOXCRVSA-N
InChi Code
InChI=1S/C21H18ClF5N2O4/c1-32-9-20(31,21(25,26)27)19(12-3-5-15(33-2)18(24)17(12)22)29-14-8-10(23)7-13-11(14)4-6-16(30)28-13/h3-8,19,29,31H,9H2,1-2H3,(H,28,30)/t19-,20?/m0/s1
SMILES Code
O=C(N1)C=CC(C1=CC(F)=C2)=C2N[C@H]([C@@](O)(C(F)(F)F)COC)C3=CC=C(OC)C(F)=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 492.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Günther C, Kowal K, Schmidt T, Jambrecina A, Toner F, Nave R. Comparison of In Vitro and In Vivo Percutaneous Absorption Across Human Skin Using BAY1003803 Formulated as Ointment and Cream. Clin Pharmacol Drug Dev. 2020 Jul;9(5):582-592. doi: 10.1002/cpdd.736. Epub 2019 Oct 24. PMID: 31647607; PMCID: PMC7383986.