Azoffluxin | CAS#2883514-82-5 | Oxindole efflux inhibitor

MedKoo Cat#: 463725 | Name: Azoffluxin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azoffluxin is a novel oxindole efflux inhibitor, enhancing azole efficacy in a Cdr1-dependent manner, being active against diverse C. auris strains, displaying activity against azole-resistant C. albicans.

Chemical Structure

Azoffluxin

CAS#2883514-82-5

Theoretical Analysis

MedKoo Cat#: 463725

Name: Azoffluxin

CAS#: 2883514-82-5

Chemical Formula: C34H34FNO9

Exact Mass: 619.2218

Molecular Weight: 619.64

Elemental Analysis: C, 65.90; H, 5.53; F, 3.07; N, 2.26; O, 23.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Azoffluxin; CMLD012336; CMLD 012336 CMLD-012336;

IUPAC/Chemical Name

6-fluoro-3,3-bis(6-(((R)-2-hydroxy-4-methylpent-4-en-1-yl)oxy)benzo[d][1,3]dioxol-5-yl)indolin-2-one

InChi Key

AORMGRZYXMMKLB-FGZHOGPDSA-N

InChi Code

InChI=1S/C34H34FNO9/c1-18(2)7-21(37)14-40-27-12-31-29(42-16-44-31)10-24(27)34(23-6-5-20(35)9-26(23)36-33(34)39)25-11-30-32(45-17-43-30)13-28(25)41-15-22(38)8-19(3)4/h5-6,9-13,21-22,37-38H,1,3,7-8,14-17H2,2,4H3,(H,36,39)/t21-,22-/m1/s1

SMILES Code

O=C1NC2=C(C=CC(F)=C2)C1(C3=C(OC[C@H](O)CC(C)=C)C=C(OCO4)C4=C3)C5=C(OC[C@H](O)CC(C)=C)C=C(OCO6)C6=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 619.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. PMID: 33353950.