MedKoo Cat#: 576516 | Name: ICI-153110

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-153110 is a cyclic nucleotide phosphodiesterase inhibitor.

Chemical Structure

ICI-153110
ICI-153110
CAS#87164-90-7

Theoretical Analysis

MedKoo Cat#: 576516

Name: ICI-153110

CAS#: 87164-90-7

Chemical Formula: C11H11N3O

Exact Mass: 201.0902

Molecular Weight: 201.23

Elemental Analysis: C, 65.66; H, 5.51; N, 20.88; O, 7.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICI 153110; ICI153110; ICI-153110
IUPAC/Chemical Name
3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-pyridinyl)ethenyl)-, (E)-
InChi Key
NTIZSASEORJCSP-OWOJBTEDSA-N
InChi Code
InChI=1S/C11H11N3O/c15-11-4-3-10(13-14-11)2-1-9-5-7-12-8-6-9/h1-2,5-8H,3-4H2,(H,14,15)/b2-1+
SMILES Code
O=C1CCC(=NN1)\C=C\c2ccncc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 201.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Murray KJ, England PJ. Inhibitors of cyclic nucleotide phosphodiesterases as therapeutic agents. Biochem Soc Trans. 1992 May;20(2):460-4. doi: 10.1042/bst0200460. PMID: 1327922. 2. McKillop D, Pickup KJ. Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents. Biochem Pharmacol. 1991 Feb 1;41(3):411-7. doi: 10.1016/0006-2952(91)90538-g. PMID: 1994899. 3. Westwood FR, Iswaran TJ, Greaves P. Long-term effects of an inotropic phosphodiesterase inhibitor (ICI 153,110) on the rat salivary gland, harderian gland, and intestinal mucosa. Toxicol Pathol. 1991;19(3):214-23. doi: 10.1177/019262339101900303. PMID: 1780638. 4. Westwood FR, Iswaran TJ, Greaves P. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990 May;14(4):797-809. doi: 10.1016/0272-0590(90)90304-3. PMID: 2361578. 5. Jafri SM, Reddy BR, Budzinski D, Goldberg AD, Pilla A, Levine TB. Acute neurohormonal and hemodynamic response to a new peak III phosphodiesterase inhibitor (ICI 153,110) in patients with chronic heart failure. J Cardiovasc Pharmacol. 1990 Sep;16(3):360-6. doi: 10.1097/00005344-199009000-00003. PMID: 1700205.