Quinocide | CAS# 525-61-1 | proteomics agent

MedKoo Cat#: 412833 | Name: Quinocide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinocide is a biochemical for proteomics research

Chemical Structure

Quinocide

CAS#525-61-1 (free base)

Theoretical Analysis

MedKoo Cat#: 412833

Name: Quinocide

CAS#: 525-61-1 (free base)

Chemical Formula: C15H21N3O

Exact Mass: 259.1685

Molecular Weight: 259.35

Elemental Analysis: C, 69.47; H, 8.16; N, 16.20; O, 6.17

Price and Availability

Size	Price	Availability	Quantity
15mg	USD 1,950.00	2 Weeks

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Related CAS #

525-61-1 (free base) 64992-36-5 (phosphoric acid)

Synonym

Quinocide; NSC50986; NSC-50986; NSC 50986

IUPAC/Chemical Name

1,4-Pentanediamine, N1-(6-methoxy-8-quinolinyl)- (9CI)

InChi Key

NBAFIBBHADOTMU-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H21N3O/c1-11(16)5-3-7-17-14-10-13(19-2)9-12-6-4-8-18-15(12)14/h4,6,8-11,17H,3,5,7,16H2,1-2H3

SMILES Code

CC(N)CCCNC1=C2N=CC=CC2=CC(OC)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Quinocide works by targeting the inflammatory response in the body by blocking the action of cyclooxygenase (COX) enzymes. By blocking the action of COX enzymes, Quinocide reduces the levels of prostaglandins in the body, which in turn reduces inflammation.

In vitro activity:

This study proposed a capillary electrophoretic method for the baseline separation of primaquine diphosphate and quinocide (a major contaminant) in pharmaceutical formulations. Reference: Biomed Chromatogr. 2009 Mar;23(3):295-301. https://pubmed.ncbi.nlm.nih.gov/18816453/

In vivo activity:

The discovery of antimalarial properties of derivatives of 8-aminoquinolines (including quinocide) had promising effectiveness of mass administration. For anti-relapse treatment and pre-epidemic prophylaxis, a short treatment course of quinocide was shown to be as effective as a longer course of acriquine with plasmocide. However, it is important to note that this study is from 1960 USSR; there is little modern data supporting these findings. Reference: Bull World Health Organ. 1960;22(6):641-62. https://pubmed.ncbi.nlm.nih.gov/14419205/

Preparing Stock Solutions

The following data is based on the product molecular weight 259.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Elbashir AA, Saad B, Ali AS, Saleh MI, Aboul-Enein HY. Enantioselective analysis of primaquine and its impurity quinocide by capillary electrophoresis. Biomed Chromatogr. 2009 Mar;23(3):295-301. doi: 10.1002/bmc.1113. PMID: 18816453. 2. Lysenko AY. Use of quinocide in treatment and prophylaxis of vivax malaria. Bull World Health Organ. 1960;22(6):641-62. PMID: 14419205; PMCID: PMC2555349.

In vitro protocol:

In vivo protocol:

1. Lysenko AY. Use of quinocide in treatment and prophylaxis of vivax malaria. Bull World Health Organ. 1960;22(6):641-62. PMID: 14419205; PMCID: PMC2555349.

1: Elbashir AA, Saad B, Ali AS, Saleh MI, Aboul-Enein HY. Determination of quinocide as impurity in primaquine tablets by capillary zone electrophoresis. Biomed Chromatogr. 2009 May;23(5):464-71. doi: 10.1002/bmc.1137. PMID: 19016231. 2: Brondz I, Fialkov AB, Amirav A. Analysis of quinocide in unprocessed primaquine diphosphate and primaquine diphosphate tablets using gas chromatography-mass spectrometry with supersonic molecular beams. J Chromatogr A. 2009 Jan 30;1216(5):824-9. doi: 10.1016/j.chroma.2008.11.043. Epub 2008 Nov 21. Erratum in: J Chromatogr A. 2009 Mar 20;1216(12):2609-10. PMID: 19108846. 3: LYSENKO AY. Use of quinocide in treatment and prophylaxis of vivax malaria. Bull World Health Organ. 1960;22(6):641-62. PMID: 14419205; PMCID: PMC2555349. 4: MARUASHVILI GM, BAKRADZE TL, KANDELAKI NS, VEKUA MA, KARDAVA AG. Lechenie bol'nykh maliariei khinotsidom [Quinocide therapy of malaria]. Med Parazitol (Mosk). 1958 Jul-Aug;27(4):406-8. Russian. PMID: 13589459. 5: Brondz I, Ekeberg D, Bell DS, Annino AR, Hustad JA, Svendsen R, Vlachos V, Oakley P, Langley GJ, Mohini T, Amaury CG, Mikhalitsyn F. Nature of the main contaminant in the drug primaquine diphosphate: SFC and SFC-MS methods of analysis. J Pharm Biomed Anal. 2007 Feb 19;43(3):937-44. doi: 10.1016/j.jpba.2006.09.017. Epub 2006 Oct 31. PMID: 17079107. 6: Elbashir AA, Saad B, Ali AS, Saleh MI, Aboul-Enein HY. Enantioselective analysis of primaquine and its impurity quinocide by capillary electrophoresis. Biomed Chromatogr. 2009 Mar;23(3):295-301. doi: 10.1002/bmc.1113. PMID: 18816453. 7: Elbashir AA, Suliman FE, Saad B, Aboul-Enein HY. Capillary electrophoretic separation and computational modeling of inclusion complexes of beta- cyclodextrin and 18-crown-6 ether with primaquine and quinocide. Biomed Chromatogr. 2010 Apr;24(4):393-8. doi: 10.1002/bmc.1304. PMID: 19650150. 8: Brondz I, Mantzilas D, Klein U, Ekeberg D, Hvattum E, Lebedeva MN, Mikhailitsyn FS, Souleimanov GD, Røe J. Nature of the main contaminant in the anti malaria drug primaquine diphosphate: a qualitative isomer analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Feb 5;800(1-2):211-23. doi: 10.1016/j.jchromb.2003.09.042. PMID: 14698257. 9: Németh K, Tárkányi G, Varga E, Imre T, Mizsei R, Iványi R, Visy J, Szemán J, Jicsinszky L, Szente L, Simonyi M. Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins. J Pharm Biomed Anal. 2011 Feb 20;54(3):475-81. doi: 10.1016/j.jpba.2010.09.020. Epub 2010 Sep 19. PMID: 20943339. 10: TIBURSKAIA NA, GLADKIKH VF, GRINBERG EM. [Data on the studies of the organ of vision following administration of quinocide]. Med Parazitol (Mosk). 1959 Jul-Aug;28:454-6. Russian. PMID: 13838302.