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MedKoo Cat#: 412829 | Name: Dimethisoquin hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethisoquin hydrochloride is a topical anesthetic used as an antipruritic.

Chemical Structure

Dimethisoquin hydrochloride
Dimethisoquin hydrochloride
CAS#2773-92-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 412829

Name: Dimethisoquin hydrochloride

CAS#: 2773-92-4 (HCl)

Chemical Formula: C17H25ClN2O

Exact Mass: 0.0000

Molecular Weight: 308.85

Elemental Analysis: C, 66.11; H, 8.16; Cl, 11.48; N, 9.07; O, 5.18

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Related CAS #
2773-92-4 (HCl) 86-80-6 (free base)
Synonym
Dimethisoquin HCl; Quinisocaine hydrochloride; Quinisocaine HCl;
IUPAC/Chemical Name
2-(3-butylisoquinolin-1-yl)oxy-N,N-dimethylethanamine;hydrochloride
InChi Key
SEYCAKMZVYADRS-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H24N2O.ClH/c1-4-5-9-15-13-14-8-6-7-10-16(14)17(18-15)20-12-11-19(2)3;/h6-8,10,13H,4-5,9,11-12H2,1-3H3;1H
SMILES Code
CCCCC1=CC2=C(C(OCCN(C)C)=N1)C=CC=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Dimethisoquin hydrochloride is a topical anesthetic used as an antipruritic.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 308.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: ROBINSON MM. Use of dimethisoquin in pruritic dermatoses: a three year study. South Med J. 1957 Mar;50(3):367-9. doi: 10.1097/00007611-195703000-00015. PMID: 13409110. 2: Gentry CL, Lukas RJ. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48. PMID: 11714893. 3: McPartland JM. Travell trigger points--molecular and osteopathic perspectives. J Am Osteopath Assoc. 2004 Jun;104(6):244-9. PMID: 15233331. 4: Boyd ND, Cohen JB. Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and 22Na+ ion fluxes. Biochemistry. 1984 Aug 28;23(18):4023-33. doi: 10.1021/bi00313a003. PMID: 6091734. 5: Dunn SM, Blanchard SG, Raftery MA. Effects of local anesthetics and histrionicotoxin on the binding of carbamoylcholine to membrane-bound acetylcholine receptor. Biochemistry. 1981 Sep 15;20(19):5617-24. doi: 10.1021/bi00522a041. PMID: 7295697. 6: Nishizawa Y, Gusovsky F, Daly JW. Local anesthetics: stimulation of incorporation of inositol into phosphoinositides in guinea pig cerebral cortical synaptoneurosomes. Biochim Biophys Acta. 1990 Sep 1;1054(2):213-8. doi: 10.1016/0167-4889(90)90243-7. PMID: 2169310. 7: Neubig RR, Cohen JB. Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions. Biochemistry. 1979 Nov 27;18(24):5464-75. doi: 10.1021/bi00591a032. PMID: 518850. 8: Cohen JB, Weber M, Changeux JP. Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata. Mol Pharmacol. 1974 Nov;10(6):904-32. PMID: 25771543. 9: GROLNICK M. Case reports; sensitization to quotane and to para-aminobenzoic acid derivatives; report of a case with cross-sensitization reactions. N Y State J Med. 1953 Feb 15;53(4):442-4. English, Undetermined Language. PMID: 13025769. 10: DALY JF. Contact dermatitis due to quotane. AMA Arch Derm Syphilol. 1952 Sep;66(3):393-4. doi: 10.1001/archderm.1952.01530280097015. PMID: 14952029.

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