PF-06843195 is a potent and selective PI3Kα Inhibitor. The phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway is a frequently dysregulated pathway in human cancer, and PI3Kα is one of the most frequently mutated kinases in human cancer. A PI3Kα-selective inhibitor may provide the opportunity to spare patients the side effects associated with broader inhibition of the class I PI3K family.
MedKoo Cat#: 463698
Name: PF-06843195
CAS#: unknown
Chemical Formula: C20H25F3N8O4
Exact Mass: 498.1951
Molecular Weight: 498.47
Elemental Analysis: C, 48.19; H, 5.06; F, 11.43; N, 22.48; O, 12.84
The following data is based on the product molecular weight 498.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
