PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1). PF-06684511 was identified as a candidate PET ligand for imaging BACE1 in the brain and showed high specific binding in an initial assessment in a nonhuman primate study.
MedKoo Cat#: 531356
Name: PF-06663195
CAS#: 1621585-22-5
Chemical Formula: C18H18F3N3O2S
Exact Mass: 397.1072
Molecular Weight: 397.42
Elemental Analysis: C, 54.40; H, 4.57; F, 14.34; N, 10.57; O, 8.05; S, 8.07
The following data is based on the product molecular weight 397.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
