SIPI-7623 | FXR Antagonist

MedKoo Cat#: 564954 | Name: SIPI-7623

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIPI7623 is a farnesoid X receptor antagonist.

Chemical Structure

SIPI-7623

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564954

Name: SIPI-7623

CAS#: NONE

Chemical Formula: C22H29NO3

Exact Mass: 355.2147

Molecular Weight: 355.48

Elemental Analysis: C, 74.33; H, 8.22; N, 3.94; O, 13.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SIPI7623; SIPI-7623; SIPI 7623

IUPAC/Chemical Name

N-(5-(2,5-Dimethylphenoxy)-2-methylpentan-2-yl)-2-(4-hydroxyphenyl)acetamide

InChi Key

ZCSRDPSZGWKZFQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H29NO3/c1-16-6-7-17(2)20(14-16)26-13-5-12-22(3,4)23-21(25)15-18-8-10-19(24)11-9-18/h6-11,14,24H,5,12-13,15H2,1-4H3,(H,23,25)

SMILES Code

O=C(NC(CCCOC1=CC(C)=CC=C1C)(C)C)CC2=CC=C(O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 355.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Deng YF, Huang XL, Su M, Yu PX, Zhang Z, Liu QH, Wang GP, Liu MY. Hypolipidemic effect of SIPI-7623, a derivative of an extract from oriental wormwood, through farnesoid X receptor antagonism. Chin J Nat Med. 2018 Aug;16(8):572-579. doi: 10.1016/S1875-5364(18)30094-3. PubMed PMID: 30197122. 2: Nian SY, Wang GP, Jiang ZL, Xiao Y, Huang MH, Zhou YH, Tan XD. Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists. Mol Divers. 2019 Feb;23(1):19-33. doi: 10.1007/s11030-018-9843-2. Epub 2018 Jul 4. PubMed PMID: 29974364.